Evidence map›Paper›PMID 33423714›Full record

ArticleInfection control and hospital epidemiology2021

Subglottic suction frequency and adverse ventilator-associated events during critical illness.

Hatem O Abdallah, Melanie F Weingart, Risa Fuller, David Pegues, Rebecca Fitzpatrick, Brendan J Kelly

Open access · greenAbstract read
In one paragraph

Article in Infection control and hospital epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hatem O AbdallahDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Melanie F WeingartDepartment of Medicine, University of Colorado, Aurora, Colorado.
Risa FullerDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
David PeguesDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Rebecca FitzpatrickDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Brendan J KellyDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-2023-646X
University of Pennsylvania · USIcahn School of Medicine at Mount Sinai · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Longitudinal analysis of respiratory tract microbiome change and sequence-based infection diagnosis during mechanical ventilationK23AI121485 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI KELLY, BRENDAN JOSEPH · 2016 to 2020
$965k
ACL HHS U54CK000485NCEZID CDC HHS U54 CK000485NIAID NIH HHS K23 AI121485NIAID NIH HHS L30 AI120149
6 · The paper itself

Abstract

objectiveTracheal intubation and mechanical ventilation provide essential support for patients with respiratory failure, but the course of mechanical ventilation may be complicated by adverse ventilator-associated events (VAEs), which may or may not be associated with infection. We sought to understand how the frequency of subglottic suction, an indicator of the quantity of sputum produced by ventilated patients, relates to the onset of all VAEs and infection-associated VAEs.

designWe performed a case-crossover study including 87 patients with VAEs, and we evaluated 848 days in the pre-VAE period at risk for a VAE. SETTING AND

participantsCritically ill patients were recruited from the medical intensive care unit of an academic medical center.

methodsWe used the number of as-needed subglottic suctioning events performed per calendar day to quantify sputum production, and we compared the immediate pre-VAE period to the preceding period. We used CDC surveillance definitions for VAE and to categorize whether events were infection associated or not.

resultsSputum quantity measured by subglottic suction frequency is greater in the period immediately prior to VAE than in the preceding period. However, it does not discriminate well between infection-associated VAEs and VAEs without associated infection.

conclusionsSubglottic suction frequency may serve as a valuable marker of sputum quantity, and it is associated with risk of a VAE. However, our results require validation in a broader population of mechanically ventilated patients and intensive care settings.

Indexed as

Critical IllnessPneumonia, Ventilator-AssociatedCross-Over StudiesHumansIntensive Care UnitsRespiration, ArtificialSuctionVentilators, Mechanical

Identifiers

PMID33423714
PMCPMC8272736
OpenAlexW3119740555

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.