ReviewJournal of eating disorders2021
Abnormal bone mineral density and content in girls with early-onset anorexia nervosa.
Review in Journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders.The International journal of eating disorders · 2026Article
- High risk of disordered eating is associated with body composition, behavioural factors, and perceived stress among university students: a cross-sectional study from the UAE.Journal of nutritional science · 2026Article
- An evolutionary perspective on the genetics of anorexia nervosa.Translational psychiatry · 2025Article
- Early-onset anorexia nervosa: a scoping review and management guidelines.Journal of eating disorders · 2024Article
- Deficiency of glucocorticoid receptor in bone marrow adipocytes has mild effects on bone and hematopoiesis but does not influence expansion of marrow adiposity with caloric restriction.Frontiers in endocrinology · 2024Article
- Review
- Unique considerations for the medical care of restrictive eating disorders in children and young adolescents.Journal of eating disorders · 2023Review
- Endocrine complications of anorexia nervosa.Journal of eating disorders · 2023Review
- Association of Short-Term Changes in Menstrual Frequency, Medication Use, Weight and Exercise on Bone Mineral Density in College-Aged Women.International journal of environmental research and public health · 2022Article
- Bone Health in School Age Children: Effects of Nutritional Intake on Outcomes.Frontiers in nutrition · 2021Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly-onset anorexia nervosa (EO-AN) represents a significant clinical burden to paediatric and mental health services. The impact of EO-AN on bone mineral abnormalities has not been thoroughly investigated due to inadequate control for pubertal status. In this study, we investigated bone mineral abnormalities in girls with EO-AN regardless of pubertal development stage.
methodWe conducted a cross-sectional study of 67 girls with EO-AN (median age = 12.4 [10.9-13.7 years]) after a median duration of disease of 1.3 [0.6-2.0] years, and 67 healthy age-, sex-, pubertal status- matched control subjects. We compared relevant bone mineral parameters between groups: the total body bone mineral density [TB-BMD], the lumbar spine BMD [LS-BMD], the total body bone mineral content [TB-BMC] and the ratio of the TB-BMC to lean body mass [TB-BMC/LBM].
resultsTB-BMD, TB-BMC, LS-BMD and TB-BMC/LBM were all significantly lower in patients with AN compared to controls. In the EO-AN group, older age, later pubertal stages and higher lean body mass were associated with higher TB-BMC, TB-BMD, and LS-BMD values. DISCUSSION: Girls with EO-AN displayed deficits in bone mineral content and density after adjustment for pubertal maturation. Age, higher pubertal stage and lean body mass were identified as determinants of bone maturation in the clinical population of patients with EO-AN. Bone health should be promoted in patients, specifically in those with an onset of disorder before 14 years old and with a delayed puberty.
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