ArticleHypertension (Dallas, Tex. : 1979)2021
Association of Blood Pressure Variability and Diuretics With Cardiovascular Events in Patients With Chronic Kidney Disease Stages 1-5.
Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Blood pressure variability and its utility in acute disease and critical illness: a systematic review.BMC anesthesiology · 2025Pooled it
- Blood Pressure Variability and the Progression of Chronic Kidney Disease: a Systematic Review and Meta-Analysis.Journal of general internal medicine · 2023Pooled it
- Blood Pressure Variability and Outcomes Across Antihypertensive Regimens.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes.Diabetologia · 2026Article
- Targeting posttranslational modifications of oxidative stress pathways for the treatment of diabetic nephropathy.Journal of pharmaceutical analysis · 2026Review
- Clinical Significance of Mean and Day-to-Day Variability of Home Blood Pressure in Chronic Kidney Disease: A Retrospective Cohort Study.JMA journal · 2026Article
- Effect of blood pressure index on clinical outcomes in patients with heart failure and chronic kidney disease.ESC heart failure · 2023Article
- Therapeutic roles of thiazides and loop diuretics in blood pressure control and renal protection against chronic kidney disease.Clinical hypertension · 2023Review
- Long-term predialysis blood pressure variability and outcomes in hemodialysis patients.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Covert vascular brain injury in chronic kidney disease.Frontiers in neurology · 2022Review
- Association between Variability of Metabolic Risk Factors and Cardiometabolic Outcomes.Diabetes & metabolism journal · 2022Review
- The roles of sodium and volume overload on hypertension in chronic kidney disease.Kidney research and clinical practice · 2021Article
- Association of Post-operative Systolic Blood Pressure Variability With Mortality After Coronary Artery Bypass Grafting.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
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Abstract
Visit-to-visit blood pressure variability (BPV) is associated with cardiovascular events in the general population. Data are scarce in chronic kidney disease. We hypothesized that BPV would be associated with cardiovascular outcomes, death, and end-stage kidney disease (ESKD) and that diuretics would modify these associations in patients with chronic kidney disease. We studied US Veterans with nondialysis chronic kidney disease stages 1-5 and hypertension on nondiuretic antihypertensive monotherapy. At the time of second antihypertensive agent prescription, we propensity-matched for exposure to a loop or thiazide diuretic versus any other antihypertensive. BPV was defined as the coefficient of variation of systolic blood pressure over 6 months after second agent prescription. Cox proportional hazards regression measured associations of BPV with a primary cardiovascular event composite (fatal or nonfatal myocardial infarction or ischemic stroke; heart failure hospitalization). Secondary outcomes included all-cause death, each primary outcome component, end-stage kidney disease, and cardiovascular death. There were 31 394 participants in each group. BPV was associated with composite cardiovascular events, hazard ratio (95% CI) at second, third, fourth, and fifth versus first quintile: 1.79 (1.53-2.11), 2.32 (1.99-2.71), 2.60 (2.24-3.02), and 3.12 (2.68-3.62). Diuretics attenuated associations between the fourth and fifth BPV quintiles with composite events (
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