Evidence map›Paper›PMID 33423486›Full record

ArticleACS biomaterials science & engineering2019

PLG Bridge Implantation in Chronic SCI Promotes Axonal Elongation and Myelination.

Dominique R Smith, Courtney M Dumont, Andrew J Ciciriello, Amina Guo, Ravindra Tatineni, Mary K Munsell, Brian J Cummings, Aileen J Anderson, Lonnie D Shea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Nanoparticle and epothilone D combinatorial intervention improves motor performance and regeneration in chronic cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dominique R SmithDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Avenue, Ann Arbor, Michigan 48109, United States.
Courtney M DumontDepartment of Biomedical Engineering, University of Miami, 1251 Memorial Drive, Coral Gables, Florida 33156, United States.
Andrew J CicirielloDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Avenue, Ann Arbor, Michigan 48109, United States.
Amina GuoDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Avenue, Ann Arbor, Michigan 48109, United States.
Ravindra TatineniDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Avenue, Ann Arbor, Michigan 48109, United States.
Mary K MunsellDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Avenue, Ann Arbor, Michigan 48109, United States.
Brian J CummingsInstitute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, 1100 Gottschalk Medical Plaza, Irvine, California 92697, United States.
Aileen J AndersonInstitute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, 1100 Gottschalk Medical Plaza, Irvine, California 92697, United States.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, 2200 Bonisteel Avenue, Ann Arbor, Michigan 48109, United States.ORCID http://orcid.org/0000-0002-9296-9673

Funding

Controlled Release Scaffolds for Nerve RegenerationR01EB005678 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, SHEA, LONNIE D · 2007 to 2018
$6.0M
NIBIB NIH HHS R01 EB005678
6 · The paper itself

Abstract

Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and loss of bladder, bowel, and sexual function. Patients are rarely treated immediately, and this delay is associated with tissue loss and scar formation that can make regeneration at chronic time points more challenging. Herein, we investigated regeneration using a poly(lactide-

Indexed as

axonal regenerationbiomaterialschronic spinal cord injurytissue engineering

Identifiers

PMID33423486
PMCPMC11283858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.