ArticleDevelopmental psychobiology2021
Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood.
Article in Developmental psychobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.Clinical epigenetics · 2026Pooled it
- Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences.bioRxiv : the preprint server for biology · 2026Article
- Timing of adverse childhood experiences shapes epigenetic ageing and life-history outcomes.Scientific reports · 2026Article
- Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults.Oncology and therapy · 2026Article
- Is Parkinson's disease getting older? Demographic and modifiable determinants of age at onset in a large Italian tertiary care cohort.Journal of neurology · 2026Observational
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- Impact of psychosocial stress in early life on pace of aging in young adulthood.Clinical epigenetics · 2025Article
- Lifetime trauma exposure and accelerated epigenetic aging among midlife women.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Adolescent depression, childhood maltreatment, and the immune system; a role for epigenetic aging?Brain, behavior, & immunity - health · 2025Article
- Adverse childhood experiences increase the long-term accumulation of morbidity in women.Communications medicine · 2025Article
- Early-Life Adversity and Epigenetic Aging: Findings from a 17-Year Longitudinal Study.Biomolecules · 2025Article
- Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA).Aging · 2025Article
- The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- A Call to Integrate Measures of Environmental Context into Research on Maternal Brain Health.International journal of environmental research and public health · 2025Review
- Maternal childhood adversity accelerates epigenetic aging of children.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Pubertal timing as a predictor of epigenetic aging and mortality risk in young adulthood.Developmental psychology · 2025Article
- The hippo pathway: a molecular bridge between environmental cues and pace of life.BMC ecology and evolution · 2025Review
- Quantification of Epigenetic Aging in Public Health.Annual review of public health · 2025Review
- Early-Life Adversity Predicts Markers of Aging-Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women.Annals of neurology · 2025Article
- Examining Health Behaviors as Mechanisms Linking Earlier Pubertal Timing with Accelerated Epigenetic Aging in Late Adolescence.Journal of youth and adolescence · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGiven associations linking early life adversity, pubertal timing, and biological aging, we examined the direct and indirect effects of early life trauma on adult biological aging (via age of menarche).
methodsParticipants were premenopausal women (N = 183). Path models evaluated whether early life trauma predicted early pubertal timing and thereby, adult epigenetic age acceleration (indexed via four epigenetic clocks: Horvath DNAm Age, Hannum DNAm Age, DNAm PhenoAge, and DNAm GrimAge). Secondary analyses explored the effects of type of trauma (abuse and neglect) and adult chronic stress status (caregiver of child with autism and non-caregiver).
resultsEarly life trauma and earlier age at menarche independently predicted accelerated aging based on one of the four epigenetic clocks, DNAm GrimAge, though early life trauma was not associated with age of menarche. Childhood abuse, but not neglect, predicted faster epigenetic aging; results did not differ by chronic stress status.
conclusionsEarly trauma and early menarche appear to exert independent effects on DNAm GrimAge, which has been shown to be the strongest epigenetic predictor of mortality risk. This study identifies a potential correlate or determinant of accelerated epigenetic aging-menarcheal age. Future research should address the limitations of this study by using racially diverse samples.
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