Evidence map›Paper›PMID 33423214›Full record

ArticleTranslational stroke research2021

Treatment with Atorvastatin During Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke.

Yirong Yang, Lisa Y Yang, Victor M Salayandia, Jeffrey F Thompson, Michel Torbey, Yi Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

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  5. Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yirong YangCollege of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA.
Lisa Y YangDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131-0001, USA.
Victor M SalayandiaDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131-0001, USA.
Jeffrey F ThompsonCenter for Memory and Aging, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA.
Michel TorbeyDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131-0001, USA.
Yi YangDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131-0001, USA. yyang@salud.unm.edu.ORCID 0000-0003-1493-2952
University of New Mexico · US

Funding

Sphingosine 1 phosphate signaling in cerebral small vessel diseaseRF1NS110724 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, YI · 2020 to 2020
$2.6M
NINDS NIH HHS RF1 NS110724
6 · The paper itself

Abstract

We previously showed that newly formed vessels in ischemic rat brain have high blood-brain barrier (BBB) permeability at 3 weeks after stroke due to a lack of major endothelial tight junction proteins (TJPs), which may exacerbate edema in stroke patients. Atorvastatin was suggested a dose-dependent pro-angiogenic effect and ameliorating BBB permeability beyond its cholesterol-lowering effects. This study examined our hypothesis that, during vascular remodeling after stroke, treatment with atorvastatin could facilitate BBB maturation in remodeling vasculature in ischemic brain. Adult spontaneously hypertensive rats underwent middle cerebral artery occlusion with reperfusion (MCAO/RP). Atorvastatin, at dose of 3 mg/kg, was delivered daily starting at 14 days after MCAO/RP onset for 7 days. The rats were studied at multiple time points up to 8 weeks with multimodal-MRI, behavior tests, immunohistochemistry, and biochemistry. The delayed treatment of atorvastatin significantly reduced infarct size and BBB permeability, restored cerebral blood flow, and improved the neurological outcome at 8 weeks after MCAO/RP. Postmortem studies showed that atorvastatin promoted angiogenesis and stabilized the newly formed vessels in peri-infarct areas. Importantly, atorvastatin facilitated maturation of BBB properties in the new vessels by promoting endothelial tight junction (TJ) formation. Further in vivo and in vitro studies demonstrated that proliferating peri-vascular pericytes expressing neural-glial antigen 2 (NG2) mediated the role of atorvastatin on BBB maturation through regulating endothelial TJ strand formations. Our results suggested a therapeutic potential of atorvastatin in facilitating a full BBB integrity and functional stroke recovery, and an essential role for pericyte-mediated endothelial TJ formation in remodeling vasculature.

Indexed as

Brain IschemiaIschemic StrokeStrokeAnimalsAtorvastatinBlood-Brain BarrierHumansInfarction, Middle Cerebral ArteryPericytesRatsVascular RemodelingAtorvastatinAtorvastatinBBB integrityNG2Proliferating pericyteStroke recoveryVascular remodeling

Identifiers

PMID33423214
PMCPMC12161153
OpenAlexW3120156844

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.