Evidence map›Paper›PMID 33423190›Full record

ArticleMolecular and cellular biochemistry2021

Reversal of cisplatin sensitization and abrogation of cisplatin-enriched cancer stem cells in 5-8F nasopharyngeal carcinoma cell line through a suppression of Wnt/β-catenin-signaling pathway.

Sirorut Sinnung, Tavan Janvilisri, Pichamon Kiatwuthinon

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sirorut SinnungDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
Tavan JanvilisriDepartment of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Pichamon KiatwuthinonDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand. fscipmk@ku.ac.th.ORCID http://orcid.org/0000-0002-6806-9261
Kasetsart University · THMahidol University · TH

Funding

Kasetsart University Research and Development Institute P-3.1(D)41.61
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is one of the rare cancers in western countries but predominant in Southeast Asian countries including Thailand. One major cause for failure of NPC chemotherapeutic treatments is reportedly correlated with the elevation of cancer stem cell (CSC) fractions. Thus, this present study aims to investigate the effect of cisplatin (CDDP) treatment on the enrichment of cancer stem-like cells (CSCs) and its associated signaling pathway in EBV-negative NPC cells. Cisplatin-pretreated 5-8F NPC cells (5-8F CDDP) were first generated by treating the cells with 0.5 μM cisplatin for 48 h. After the instant treatment, 5-8F CDDP showed increased IC

Indexed as

Cell Line, TumorCisplatinHumansNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNeoplastic Stem CellsWnt Signaling PathwayCisplatinCancer stem cellCisplatinNasopharyngeal carcinomaTankyrase inhibitorWnt/β-catenin signaling

Identifiers

PMID33423190
OpenAlexW3120481396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.