Evidence map›Paper›PMID 33422890›Full record

ArticleNeurobiology of aging2021

The value of multimodal imaging with

Toji Miyagawa, Scott A Przybelski, Daniela Maltais, Hoon-Ki Min, Lennon Jordan, Timothy G Lesnick, Qin Chen, Jonathan Graff-Radford, David Jones, Rodolfo Savica and 14 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01453127 (DaTSCAN Imaging in Aging and Neurodegenerative Disease), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01453127 phase4enrolling by invitationnot on this map

DaTSCAN Imaging in Aging and Neurodegenerative Disease

TypeinterventionalSponsorMayo ClinicRan2011 to 2026Enrolled500ConditionsDementia, Parkinsonism, Mild Cognitive Impairment, REM Sleep Behavior DisorderArmsI-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Heterogeneity of dementia with lewy bodies: Insights from clinical presentations, neuropathology, and biomarkers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 1 country.

Toji MiyagawaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Scott A PrzybelskiDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Daniela MaltaisDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Hoon-Ki MinDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Lennon JordanDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Timothy G LesnickDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Qin ChenDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
David JonesDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Rodolfo SavicaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
David KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Ronald PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Walter K KremersDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Leah K ForsbergDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Tanis J FermanDepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA.
Laura AllenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Joseph ParisiDepartment of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
R Ross ReichardDepartment of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
Melissa MurrayDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Dennis DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: vlowe@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USMayo Clinic · USWinnMed · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI DENNIS WILLIAM DICKSON · 2019 to 2026
$33.5M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
NEUROPSYCHOLOGY OF DEMENTIA WITH LEWY BODIESR01AG015866 · NIA · MAYO CLINIC JACKSONVILLE · PI FERMAN, TANIS JILL · 1999 to 2009
$2.6M
NIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG015866NIA NIH HHS U01 AG006786NICHD NIH HHS K12 HD065987NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[

Indexed as

Alzheimer DiseaseBrainDiagnosis, DifferentialFemaleHumansIodine RadioisotopesLewy Body DiseaseMagnetic Resonance ImagingMaleMultimodal ImagingPositron-Emission TomographyRadiopharmaceuticalsSoftwareTomography, Emission-Computed, Single-PhotonTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneIodine RadioisotopesRadiopharmaceuticalsTropanes(123)I-FP-CIT SPECTDaTQUANTDementia with Lewy bodiesFDG-PETMRIPiB-PET

Identifiers

PMID33422890
PMCPMC7902470
OpenAlexW3112720495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.