Evidence map›Paper›PMID 33422810›Full record

ReviewJournal of critical care2021

Major publications in the critical care pharmacotherapy literature: 2019.

Melanie Smith Condeni, Alyson T Basting, Patrick G Costello, Ashley DePriest, Evert A Eriksson, Heather Evans, Kristie Hertel, Andre L Holder, Alyssa N Kester, Kinsey R Kowalski and 6 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of critical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Comparison of vasopressin-first weaning versus norepinephrine-first weaning in critically ill patients.International journal of clinical pharmacology and therapeutics · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 1 country.

Melanie Smith CondeniMedical University of South Carolina, 150 Ashley Avenue, Charleston, SC 29425, USA. Electronic address: smitmela@musc.edu.
Alyson T BastingIndiana University Health Arnett Hospital, 5165 McCarty Ln, Lafayette, IN 47905, USA. Electronic address: abasting@iuhealth.org.
Patrick G CostelloUniversity of Chicago Medical Center, 5841 S. Maryland Avenue, Chicago, IL 60637, USA. Electronic address: Patrick.Costello@uchospitals.edu.
Ashley DePriestWellstar Kennestone Regional Medical Center, 677 Church Street, Marietta, GA 30060, USA. Electronic address: adepriest@gmh.edu.
Evert A ErikssonMedical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA. Electronic address: eriksson@musc.edu.
Heather EvansMedical University of South Carolina, 96 Jonathan Lucas St, Room CSB 426, Charleston, SC 29425, USA. Electronic address: evanshe@musc.edu.
Kristie HertelVidant Medical Center, 2100 Stantonsburg Road, Greenville, NC 27831, USA.
Andre L HolderEmory University School of Medicine, Grady Memorial Hospital, 80 Jesse Hill Jr Drive SE, Rm 2D012, Atlanta, GA 30303, USA. Electronic address: Andre.holder@emory.edu.
Alyssa N KesterSt. Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA 18015, USA. Electronic address: Alyssa.Kester@sluhn.org.
Kinsey R KowalskiOchsner Medical Center, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Electronic address: Kinsey.kowalski@ochsner.org.
Carolyn Magee BellMedical University of South Carolina, 150 Ashley Ave MSC 584, Charleston, SC 29425, USA. Electronic address: mageeca@musc.edu.
Barbara McLeanGrady Health Systems, Atlanta, GA 30303, USA.
Michael ReichertEmory Hillandale Hospital, 2801 Dekalb Medical Parkway, Lithonia, GA 30058, USA.
Melissa SantibañezLarkin University, College of Pharmacy, 18301 North Miami Avenue, Miami, FL 33169, USA. Electronic address: msantibanez@ularkin.org.
Patrick M WieruszewskiMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: wieruszewski.patrick@mayo.edu.
Andrea Sikora NewsomeThe University of Georgia College of Pharmacy, 1120 15(th) St, HM-118, Augusta, GA 30912, USA. Electronic address: sikora@uga.edu.
Medical University of South Carolina · USDeKalb Medical Center · USGrady Health System · USGrady Memorial Hospital · USIndiana University Health · USLarkin University · USMayo Clinic · USOchsner Medical Center · USSt. Luke's University Health Network · USUniversity of Chicago Medical Center · USVidant Medical Center · USWellStar Kennestone Hospital · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378NIA NIH HHS U54 AG062334
6 · The paper itself

Abstract

purposeTo summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019. MATERIALS AND

methodsThe Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 36 journals monthly for impactful articles and reviewed 113 articles during 2019 according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria.

resultsArticles with a 1A grade, including three clinical practice guidelines, six meta-analyses, and five original research trials are reviewed here from those included in the monthly CCPLU. Clinical practice guidelines on the use of polymyxins and antiarrhythmic drugs in cardiac arrest as well as meta-analyses on antipsychotic use in delirium, stress ulcer prophylaxis (SUP), and vasoactive medications in septic shock and cardiac arrest were summarized. Original research trials evaluated delirium, sedation, neuromuscular blockade, SUP, anticoagulation reversal, and hemostasis.

conclusionThis clinical review and expert opinion provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2019.

Indexed as

Peptic UlcerShock, SepticCritical CareHumansCardiac arrestCritical careDrug therapyGuidelineReviewSeptic shock

Identifiers

PMID33422810
PMCPMC7970328
OpenAlexW3114314200

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.