ArticleOsteoarthritis and cartilage2021
Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.
Article in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Pooled it
- Mendelian Randomization Studies of Lifestyle-Related Risk Factors for Osteoarthritis: A PRISMA Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Exploring the role of inflammatory cytokines in obesity-mediated MASLD development and drug target identification.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Causal association between rheumatoid arthritis and periodontitis: A Mendelian randomization study.Medicine · 2026Article
- Triglyceride-glucose related indices, cardiometabolic multimorbidity, and risk of incident osteoarthritis: A prospective cohort study in UK Biobank.Therapeutic advances in musculoskeletal disease · 2026Article
- Unraveling the connection between obesity, metabolic syndrome and osteoarthritis risk: a large-observational study.Diabetology & metabolic syndrome · 2025Article
- Smoking can increase the risk of osteoarthritis in European women.Scientific reports · 2025Article
- Revealing the mediating mechanisms between BMI and osteoarthritis: a Mendelian randomization and mediation analysis.Aging clinical and experimental research · 2025Article
- Celiac Disease as a Genetic Predisposing Factor for Dermatitis Herpetiformis: A Two-Sample Mendelian Randomization Analysis.Clinical, cosmetic and investigational dermatology · 2025Article
- The Causal Effects of Lifestyle Factors on Osteoarthritis: A Two-sample Mendelian Randomisation Study.Current rheumatology reviews · 2025Article
- Osteoarthritis as a clinical marker of cardiovascular-kidney-metabolic multimorbidity: a population-based cohort study in China.Frontiers in endocrinology · 2025Article
- Unraveling the genetic basis of metabolic traits and benign adrenal tumors: a comprehensive causal analysis.International journal of clinical and experimental pathology · 2025Article
- Association Between Serum Uric Acid Levels and Skin Cancer: Results from NHANES Data and Mendelian Randomization Analysis.Clinical, cosmetic and investigational dermatology · 2025Article
- A Guide to Understanding Mendelian Randomization Studies.Arthritis care & research · 2024Review
- Clinical phenotypes of comorbidities in end-stage knee osteoarthritis: a cluster analysis.BMC musculoskeletal disorders · 2024Article
- Phenome-wide causal associations between osteoarthritis and other complex traits through the latent causal variable analysis.BMC musculoskeletal disorders · 2024Article
- Causal Factors for Osteoarthritis: A Scoping Review of Mendelian Randomization Studies.Arthritis care & research · 2024Article
- The association between lipid biomarkers and osteoarthritis based on the National Health and Nutrition Examination Survey and Mendelian randomization study.Scientific reports · 2024Article
- The role of inflammatory proteins in regulating the impact of lipid specifications on deep venous thrombosis: a two sample and mediated Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate which cardiometabolic factors underlie clustering of osteoarthritis (OA) with cardiovascular disease, and the extent to which these mediate an effect of education.
designGenome-wide association study (GWAS) of OA was performed in UK Biobank (60,800 cases and 328,251 controls) to obtain genetic association estimates for OA risk. Genetic instruments and association estimates for body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), smoking and education were obtained from existing GWAS summary data (sample sizes 188,577-866,834 individuals). Two-sample Mendelian randomization (MR) analyses were performed to investigate the effects of exposure traits on OA risk. MR mediation analyses were undertaken to investigate whether the cardiometabolic traits mediate any effect of education on OA risk.
resultsMR analyses identified protective effects of higher genetically predicted education (main MR analysis odds ratio (OR) per standard deviation increase 0.59, 95% confidence interval (CI) 0.54-0.64) and LDL-C levels (OR 0.94, 95%CI 0.91-0.98) on OA risk, and unfavourable effects of higher genetically predicted BMI (OR 1.82, 95%CI 1.73-1.92) and smoking (OR 2.23, 95%CI 1.85-2.68). There was no strong evidence of an effect of genetically predicted SBP on OA risk (OR 0.98, 95% CI 0.90-1.06). The proportion of the effect of genetically predicted education mediated through genetically predicted BMI and smoking was 35% (95%CI 13-57%).
conclusionsThese findings highlight education, obesity and smoking as common mechanisms underlying OA and cardiovascular disease. These risk factors represent clinical and public health targets for reducing multi-morbidity related to the burden these common conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.