Evidence map›Paper›PMID 33422638›Full record

ArticleBrain, behavior, and immunity2021

Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.

Sathyanarayanan Rajagopal, Changjun Yang, Kelly M DeMars, Ranjana Poddar, Eduardo Candelario-Jalil, Surojit Paul

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sathyanarayanan RajagopalUniversity of New Mexico Health Sciences Center, Department of Neurology, USA.
Changjun YangUniversity of Florida, Department of Neuroscience, USA.
Kelly M DeMarsUniversity of Florida, Department of Neuroscience, USA.
Ranjana PoddarUniversity of New Mexico Health Sciences Center, Department of Neurology, USA.
Eduardo Candelario-JalilUniversity of Florida, Department of Neuroscience, USA.
Surojit PaulUniversity of New Mexico Health Sciences Center, Department of Neurology, USA; University of New Mexico Health Sciences Center, Department of Neuroscience, USA. Electronic address: spaul@salud.unm.edu.
University of Florida · USUniversity of New Mexico · US

Funding

Role of Brain Specific Tyrosne Phosphatase STEP in Neuroprotection and DeathR01NS059962 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI PAUL, SUROJIT · 2008 to 2023
$5.9M
Molecular basis of hyperhomocysteinemia induced brain injury in ischemic strokeR01NS083914 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI PODDAR, RANJANA · 2014 to 2025
$4.5M
Multi-pronged Approach to Recalibrating the Inflammatory Cascade in Ischemic Stroke with BET blockadeR01NS109816 · NINDS · UNIVERSITY OF FLORIDA · PI CANDELARIO-JALIL, EDUARDO JESUS · 2019 to 2023
$1.9M
Neurovascular Protection by Adropin in Ischemic StrokeR01NS103094 · NINDS · UNIVERSITY OF FLORIDA · PI CANDELARIO-JALIL, EDUARDO JESUS · 2018 to 2021
$1.5M
NINDS NIH HHS R01 NS059962NINDS NIH HHS R01 NS083914NINDS NIH HHS R01 NS103094NINDS NIH HHS R01 NS109816
6 · The paper itself

Abstract

The neuron-specific tyrosine phosphatase STEP is emerging as a key neuroprotectant against acute ischemic stroke. However, it remains unclear how STEP impacts the outcome of stroke. We find that the exacerbation of ischemic brain injury in STEP deficient mice involves an early onset and sustained activation of neuronal p38 mitogen activated protein kinase, a substrate of STEP. This leads to rapid increase in the expression of neuronal cyclooxygenase-2 and synthesis of prostaglandin E

Indexed as

Brain IschemiaProtein Tyrosine Phosphatases, Non-ReceptorStrokeAnimalsMiceNeuronsProtein Tyrosine Phosphatases, Non-ReceptorPtpn5 protein, mouseCerebral ischemiaCyclooxygenase-2InflammationNeuroprotectionp38 MAP kinaseProstaglandin E(2)STEPTyrosine phosphatase

Identifiers

PMID33422638
PMCPMC7979508
OpenAlexW3118476157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.