ArticlePharmacology, biochemistry, and behavior2021
Female rats display higher methamphetamine-primed reinstatement and c-Fos immunoreactivity than male rats.
Article in Pharmacology, biochemistry, and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Differences between males and females in psychostimulant/sucrose self-administration (when observed) may not necessarily be driven by biological sex.bioRxiv : the preprint server for biology · 2026Article
- The interconnected wirings between medial prefrontal cortex and claustrum and their governing roles in the methamphetamine reward memory in male mice.Nature communications · 2026Article
- Article
- Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking.Nature communications · 2025Article
- Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in rats.Addiction neuroscience · 2025Article
- The estrous cycle has no effect on incubation of methamphetamine craving and associated Fos expression in dorsomedial striatum and anterior intralaminar nucleus of thalamus.Addiction neuroscience · 2024Article
- Neuropharmacological Evidence Implicating Drug-Induced Glutamate Receptor Dysfunction in Affective and Cognitive Sequelae of Subchronic Methamphetamine Self-Administration in Mice.International journal of molecular sciences · 2024Article
- Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex.BMC neuroscience · 2023Article
- Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum.Scientific reports · 2022Article
- Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts.Neuroscience and biobehavioral reviews · 2022Review
- Appetitive Pavlovian conditioning of the stimulus effects of nicotine enhances later nicotine self-administration.Journal of the experimental analysis of behavior · 2022Article
- Sex-Specific Alterations in Dopamine Metabolism in the Brain after Methamphetamine Self-Administration.International journal of molecular sciences · 2022Article
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Authors and funding
8 authors.
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Abstract
Methamphetamine (meth) dependence is often characterized by persistent and chronic relapse (i.e., return to drug use). Previous work suggests females may be at greater risk to relapse. In this study, we extended this limited evidence and identified sex-dependent neural substrates related to meth-triggered reinstatement. Male and female Sprague-Dawley rats were implanted with indwelling jugular catheters. Half of the rats were then trained to self-administer meth (0.05 mg/kg/inf); the other half self-administered saline during 21 daily sessions (2 h). Rats were then given 12 extinction sessions. Twenty-four hours after the last extinction session, rats received reinstatement testing. Half of the rats received a meth-prime (0.3 mg/kg, IP) injection and the remaining rats received a saline injection. This design resulted in 4 separate groups for each sex, allowing for careful investigation of brain regions related to meth-triggered reinstatement. Brains were harvested following the reinstatement session and c-Fos immunoreactivity was measured in multiple brain regions. Meth triggered reinstatement in both sexes and this effect was more robust in females compared to males. Significant sex differences were detected. Females showed greater c-Fos immunoreactivity in the cingulate cortex area 1, lateral orbitofrontal cortex, prelimbic cortex, caudate-putamen, nucleus accumbens core and shell, and central nucleus of the amygdala following meth-primed reinstatement.
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