ArticleInternational journal of cardiology2021
Circulating growth factors and cardiac remodeling in the community: The Framingham Heart Study.
Article in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Aortic stiffness after living kidney donation: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- The Prognostic Potential of Insulin-like Growth Factor-Binding Protein 1 for Cardiovascular Complications in Peripheral Artery Disease.Journal of cardiovascular development and disease · 2025Article
- Data-driven cluster analysis and external validation identify phenotypic subgroups in renin-independent aldosteronism with differential cardiovascular risk and therapeutic implications.Frontiers in endocrinology · 2025Article
- Release kinetics of growth factors loaded into β-TCP ceramics in anFrontiers in bioengineering and biotechnology · 2024Article
- Improvement of physical activity significantly reduced serum hepatocyte growth factor levels in a general population: 10 year prospective study.Heart and vessels · 2023Article
- Association between angiopoietin-2 and functional cardiac remodeling in hemodialysis patients with normal left ventricular ejection.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsCardiac and vascular growth factors (GF) may influence myocardial remodeling through cardiac growth and angiogenic effects. We hypothesized that concentrations of circulating GF are associated with cardiac remodeling traits.
methodsWe related blood concentrations of vascular endothelial GF (VEGF), VEGFR-1 (sFlt1), angiopoietin 2 (Ang-2), soluble angiopoietin type-2 receptor (sTie2), hepatocyte GF (HGF), insulin-like GF (IGF)-1, IGF binding protein (IGFBP)-3, and growth differentiation factor-15 (GDF-15) to echocardiographic traits in 3151 Framingham Study participants (mean age 40 years, 55% women). We evaluated the following measures: left ventricular (LV) mass index (LVMi), LV ejection fraction (LVEF), global longitudinal strain (GLS), mitral E/e', and aortic root diameter (AoR). All biomarker values were sex-standardized.
resultsIn multivariable-adjusted analyses, higher GDF-15 concentrations were associated with higher log-LVMi (β = 0.009 per SD, P = 0.01). Similarly, sTie2 concentrations were positively associated with log-E/e' (β = 0.011 per SD, P = 0.04). IGF-1 and Ang-2 concentrations were positively and negatively associated with GLS, respectively (β
conclusionIn our large community-based sample, we observed patterns of associations between several circulating vascular GF and cardiac remodeling indices that are consistent with the known biological effects of these pro- and anti-angiogenic factors on the myocardium and conduit arteries. Additional studies are warranted to replicate our findings and assess their prognostic significance.
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