ArticleBrain research2021
Accelerated brain aging in chronic low back pain.
Article in Brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- A systematic review of brain health in adults with chronic pain.Anaesthesia · 2026Pooled it
- Neuroimaging Studies of Chronic Prostatitis/Chronic Pelvic Pain Syndrome.Pain research & management · 2022Pooled it
- Article
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Article
- Brain age mediates gut microbiome dysbiosis-related cognition in older adults.Alzheimer's research & therapy · 2025Article
- More than chronic pain: behavioural and psychosocial protective factors predict lower brain age in adults with/at risk of knee osteoarthritis over two years.Brain communications · 2025Article
- Cognition is selectively impaired in males with spinal pain: A retrospective analysis of data from the Longitudinal Study of Ageing Danish Twins.Experimental physiology · 2024Article
- Neuroimmune activation and increased brain aging in chronic pain patients after the COVID-19 pandemic onset.Brain, behavior, and immunity · 2024Article
- Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation.Frontiers in neuroscience · 2024Article
- Increased MRI-based Brain Age in chronic migraine patients.The journal of headache and pain · 2023Article
- Association between functional disability with postural balance among patients with chronic low back pain.Frontiers in neurology · 2023Article
- Mechanisms behind the Development of Chronic Low Back Pain and Its Neurodegenerative Features.Life (Basel, Switzerland) · 2022Review
- Independent replication of advanced brain age in mild cognitive impairment and dementia: detection of future cognitive dysfunction.Molecular psychiatry · 2022Article
- Age and Sex in Back Pain Intensity-Retrospective Study of Conservatory vs. Surgical Discopathy Treatment.Life (Basel, Switzerland) · 2022Article
- Neuroimaging-Based Brain Age Estimation: A Promising Personalized Biomarker in Neuropsychiatry.Journal of personalized medicine · 2022Review
- The ALFF Alterations of Spontaneous Pelvic Pain in the Patients of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Evaluated by fMRI.Brain sciences · 2022Article
- Cerebral structural alterations in the patients undergoing postherpetic neuralgia: A VBM-MRI study.Ibrain · 2022Article
- A training program for researchers in population neuroimaging: Early experiences.Frontiers in neuroimaging · 2022Review
- Do Patients of Chronic Low Back Pain have Psychological Comorbidities?Avicenna journal of medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chronic low back pain (CLBP) is a leading cause of disability and is associated with neurodegenerative changes in brain structure. These changes lead to impairments in cognitive function and are consistent with those seen in aging, suggesting an accelerated aging pattern. In this study we assessed this using machine-learning estimated brain age (BA) as a holistic metric of morphometric changes associated with aging. Structural imaging data from 31 non-depressed CLBP patients and 32 healthy controls from the Pain and Interoception Imaging Network were included. Using our previously developed algorithm, we estimated BA per individual based on grey matter density. We then conducted multivariable linear modeling for effects of group, chronological age, and their interaction on BA. We also performed two voxel-wise analyses comparing grey matter density between CLBP and control individuals and the association between gray matter density and BA. There was an interaction between CLBP and greater chronological age on BA such that the discrepancy in BA between healthy and CLBP individuals was greater for older individuals. In CLBP individuals, BA was not associated with sex, current level of pain, duration of CLBP, or mild to moderate depressive symptoms. CLBP individuals had lower cerebellar grey matter density compared to healthy individuals. Brain age was associated with lower gray matter density in numerous brain regions. CLBP was associated with greater BA, which was more profound in later life. BA as a holistic metric was sensitive to differences in gray matter density in numerous regions which eluded direct comparison between groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.