Evidence map›Paper›PMID 33421755›Full record

ReviewCurrent opinion in cell biology2021

Nuclear envelope remodelling during mitosis.

Gautam Dey, Buzz Baum

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  12. Mitotic spindle membranes.Molecular biology of the cell · 2025
    Review
  13. Article
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  19. Review
  20. Confinement-sensitive volume regulation dynamics via high-speed nuclear morphological measurements.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gautam DeyCell Biology and Biophysics, European Molecular Biology Laboratory, 69117, Heidelberg, Germany. Electronic address: gautam.dey@embl.de.
Buzz BaumLab of Molecular Biology, Cambridge, CB2 0QH, United Kingdom; Lab for Molecular Cell Biology, UCL, London, WC1E 6BT, United Kingdom. Electronic address: bbaum@mrc-lmb.cam.ac.uk.

Funding

Medical Research Council MC_UP_1201/27Wellcome TrustWellcome Trust 203276/Z/16/Z
6 · The paper itself

Abstract

The defining feature of the eukaryotic cell, the nucleus, is bounded by a double envelope. This envelope and the nuclear pores within it play a critical role in separating the genome from the cytoplasm. It also presents cells with a challenge. How are cells to remodel the nuclear compartment boundary during mitosis without compromising nuclear function? In the two billion years since the emergence of the first cells with a nucleus, eukaryotes have evolved a range of strategies to do this. At one extreme, the nucleus is disassembled upon entry into mitosis and then reassembled anew in the two daughter cells. At the other, cells maintain an intact nuclear compartment boundary throughout the division process. In this review, we discuss common features of the division process that underpin remodelling mechanisms, the topological challenges involved and speculate on the selective pressures that may drive the evolution of distinct modes of division.

Indexed as

MitosisNuclear EnvelopeCell NucleusCytoplasmHumansNuclear PoreEukaryogenesisLaminaMitosisNuclear divisionNuclear envelopeNuclear pore complex

Identifiers

PMID33421755
PMCPMC8129912

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.