Evidence map›Paper›PMID 33421713›Full record

ReviewCurrent opinion in neurobiology2021

Developmental mechanisms underlying circuit wiring: Novel insights and challenges ahead.

Heike Blockus, Franck Polleux

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. FASN-dependent de novo lipogenesis is required for brain development.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Heike BlockusDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA. Electronic address: hb2505@columbia.edu.
Franck PolleuxDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA. Electronic address: fp2304@columbia.edu.
Columbia University · US

Funding

Slit-Robo signaling links synapse specificity with functional circuit wiringR21NS109753 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI POLLEUX, FRANCK · 2019 to 2019
$446k
Exploring new roles of Robo2 in synaptic development, plasticity and hippocampal circuit functionK99NS115984 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLOCKUS, HEIKE MANUELA · 2020 to 2020
$120k
NINDS NIH HHS K99 NS115984NINDS NIH HHS R21 NS109753
6 · The paper itself

Abstract

Synaptic connectivity within neural circuits is characterized by high degrees of cellular and subcellular specificity. This precision arises from the combined action of several classes of molecular cues, transmembrane receptors, secreted cues and extracellular matrix components, coordinating transitions between axon guidance, dendrite patterning, axon branching and synapse specificity. We focus this review on recent insights into some of the molecular and cellular mechanisms controlling these transitions and present the results of large-scale efforts and technological developments aimed at mapping neural connectivity at single cell resolution in the mouse cortex as a mammalian model organism. Finally, we outline some of the technical and conceptual challenges lying ahead as the field is starting to explore one of the most challenging problems in neuroscience: the molecular and cellular logic underlying the emergence of the connectome characterizing specific circuits within the central nervous system of mammals.

Indexed as

ConnectomeSynapsesAnimalsAxon GuidanceCuesMice

Identifiers

PMID33421713
PMCPMC8058300
OpenAlexW3118302788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.