Evidence map›Paper›PMID 33421656›Full record

ArticleSurgical oncology2021

A proposed Clino-radio-pathological Risk Scoring System (CRiSS) for prediction and management of inguinal lymph-nodes metastasis in squamous cell carcinoma of the penis.

Keval N Patel, Chirag Bhirud, J Dipin, Kunal Nandy, Vivek Venugopal, Abhijeet Salunke, Shashank J Pandya

Abstract read
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Article in Surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Keval N PatelConsultant Uro Oncologist, Department of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Electronic address: drkevalpatel@yahoo.com.
Chirag Bhirud2nd-year Resident. Department of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Electronic address: chirag.bhirud@gmail.com.
J Dipin2nd-year Resident. Department of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Electronic address: drdipinj@gmail.com.
Kunal Nandy2nd-year Resident. Department of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Electronic address: kunalnandy@gmail.com.
Vivek Venugopal1st-year Resident. Department of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Electronic address: vivek.venu@hotmail.com.
Abhijeet SalunkeConsultant Ortho Oncosurgeon, Department of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Electronic address: drabhijeetsalunke@gmail.com.
Shashank J PandyaDepartment of Surgical Oncology, The Gujarat Cancer Research Institute, Ahmedabad, Gujarat, India. Electronic address: shashank.pandya@gcriindia.org.
Gujarat Cancer & Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo develop a risk scoring system for prediction of inguinal lymph-node involvement and to suggest a management strategy according to the risk groups based on clinical, radiological and pathological parameters in squamous cell carcinoma (SCC) of penis. MATERIALS AND

methodsA retrospective analysis of all patients of SCC penis from 2014 to 2020 at our institute was done. The patients were divided into derivation cohort (2014 to 2019) and validation cohort (2019 to 2020). A total of 10 predictors were analysed in univariate analysis and those found significant were further subjected to multivariate analysis to derive regression coefficient for each. CRiSS scores were assigned based on the coefficients and three groups were created which were correlated with nodal metastasis. The predictive accuracy of the model was assessed by ROC analysis of the derivation cohort and validation cohort.

resultsA total of 102 patients were identified in derivation cohort and 23 patients in validation cohort. Size of the primary >3cm, ulceroinfiltrative growth, involving shaft, ultrasound size of lymph-nodes >1cm, loss of fatty hila, moderate and poor differentiation, and lypmphovascular/perineural invasion were independent predictors of inguinal lymphnode metastasis in multivariate analysis. CRiSS could achieve AUROC of .910 and .887 in derivation and validation cohort respectively. The rate of metastatic lymphadenopathy was 0%, 41.4%, and 89.5% in low, intermediate, and high-risk groups respectively.

conclusionsCRiSS can effectively predict inguinal lymph-node metastasis in SCC penis. We suggest a management strategy based on risk groups that will avoid morbidity of groin dissection in many patients.

Indexed as

Carcinoma, Squamous CellCase-Control StudiesDisease ManagementFollow-Up StudiesHumansInguinal CanalLymphatic MetastasisLymph Node ExcisionLymph NodesMaleMiddle AgedPenile NeoplasmsPrognosisRetrospective StudiesRisk FactorsCancer of penisInguinal lymph-nodes metastasisScoring methods

Identifiers

PMID33421656
OpenAlexW3117914164

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.