Evidence map›Paper›PMID 33421563›Full record

ArticleNeurobiology of disease2021

FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner.

Katherine M Bland, Adam Aharon, Eden L Widener, M Irene Song, Zachary O Casey, Yi Zuo, George S Vidal

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. mTOR-Dependent Spine Dynamics in Autism.Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katherine M BlandDepartment of Biology, James Madison University, Harrisonburg, VA 22801, United States.
Adam AharonDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
Eden L WidenerDepartment of Biology, James Madison University, Harrisonburg, VA 22801, United States.
M Irene SongDepartment of Biology, James Madison University, Harrisonburg, VA 22801, United States.
Zachary O CaseyDepartment of Biology, James Madison University, Harrisonburg, VA 22801, United States.
Yi ZuoDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, United States. Electronic address: yizuo@ucsc.edu.
George S VidalDepartment of Biology, James Madison University, Harrisonburg, VA 22801, United States. Electronic address: vidalgx@jmu.edu.
James Madison University · USUniversity of California, Santa Cruz · US

Funding

Dynamics and molecular mechanism of synaptic connectivity change during learningR01MH104227 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2014 to 2018
$2.1M
Contribution of astrocytes to the Fragile X SyndromeR01MH109475 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2016 to 2020
$2.0M
Integrin Functions in Shaping Cortical CircuitsK01NS107723 · NINDS · JAMES MADISON UNIVERSITY · PI VIDAL, GEORGE · 2020 to 2024
$1.1M
NIMH NIH HHS R01 MH104227NIMH NIH HHS R01 MH109475NINDS NIH HHS K01 NS107723
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is the most common form of intellectual disability that arises from the dysfunction of a single gene-Fmr1. The main neuroanatomical correlate of FXS is elevated dendritic spine density on cortical pyramidal neurons, which has been modeled in Fmr1

Indexed as

AnimalsCerebral CortexDendritic SpinesFemaleFragile X Messenger Ribonucleoprotein 1HeterozygoteMaleMiceMice, KnockoutMosaicismPyramidal CellsX Chromosome InactivationFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Cell-autonomousCerebral cortexDendriteDendritic spineFmr1Fragile X SyndromeLayer 5Layer VMosaicPyramidal neuron

Identifiers

PMID33421563
PMCPMC7878418
OpenAlexW3120720047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.