Evidence map›Paper›PMID 33421548›Full record

ArticleExperimental hematology2021

Chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis exhibits an increased inflammatory signature that is reduced in early-stage chronic lymphocytic leukemia.

Gonzalo Blanco, Anna Puiggros, Barbara Sherry, Lara Nonell, Xavier Calvo, Eulàlia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, Gerardo Ferrer, Florencia Palacios and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Experimental hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. OCT4 and Nestin Expression in the Microenvironment of Primary Central Nervous System Lymphomas.International journal of hematology-oncology and stem cell research · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Gonzalo BlancoLaboratori de Citogenètica Molecular, Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, Barcelona, Spain; Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Anna PuiggrosLaboratori de Citogenètica Molecular, Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, Barcelona, Spain; Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Barbara SherryCenter for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY; Department of Medicine, Hofstra Northwell School of Medicine, Hempstead, NY; Department of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, NY.
Lara NonellMARGenomics, IMIM, Barcelona, Spain.
Xavier CalvoLaboratori de Citogenètica Molecular, Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, Barcelona, Spain; Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Eulàlia PuigdecanetMARGenomics, IMIM, Barcelona, Spain.
Pui Yan ChiuCenter for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY.
Yasmine KiesoKarches Center for Oncology Research, The Feinstein Institute for Medical Research, Manhasset, NY.
Gerardo FerrerKarches Center for Oncology Research, The Feinstein Institute for Medical Research, Manhasset, NY.
Florencia PalaciosKarches Center for Oncology Research, The Feinstein Institute for Medical Research, Manhasset, NY.
Magdalena ArnalMARGenomics, IMIM, Barcelona, Spain.
María Rodríguez-RiveraLaboratori de Citogenètica Molecular, Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, Barcelona, Spain; Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Eva GimenoServei d'Hematologia, Hospital del Mar-IMIM, Barcelona, Spain; Grup de Recerca Clínica Aplicada en Neoplàsies Hematològiques, Cancer Research Program, IMIM-Hospital del Mar, Barcelona, Spain.
Eugènia AbellaServei d'Hematologia, Hospital del Mar-IMIM, Barcelona, Spain; Grup de Recerca Clínica Aplicada en Neoplàsies Hematològiques, Cancer Research Program, IMIM-Hospital del Mar, Barcelona, Spain.
Kanti R RaiDepartment of Medicine, Hofstra Northwell School of Medicine, Hempstead, NY; Karches Center for Oncology Research, The Feinstein Institute for Medical Research, Manhasset, NY.
Pau AbrisquetaServei d'Hematologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Francesc BoschServei d'Hematologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Alexandre CalonLaboratori de Recerca Translacional en Microambient Tumoral, Cancer Research Program, IMIM, Barcelona, Spain.
Ana FerrerLaboratori de Citogenètica Molecular, Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, Barcelona, Spain; Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Nicholas ChiorazziDepartment of Medicine, Hofstra Northwell School of Medicine, Hempstead, NY; Department of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, NY; Karches Center for Oncology Research, The Feinstein Institute for Medical Research, Manhasset, NY.
Blanca EspinetLaboratori de Citogenètica Molecular, Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, Barcelona, Spain; Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. Electronic address: bespinet@parcdesalutmar.cat.
Hospital Del Mar · ESFeinstein Institute for Medical Research · USMunicipal Institute for Medical Research · ESVall d'Hebron Hospital Universitari · ES

Funding

Th17 generation, action and therapeutic relevance in chronic lymphocytic leukemiaR01CA238523 · NCI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CHIORAZZI, NICHOLAS, SHERRY, BARBARA A · 2020 to 2024
$2.7M
NCI NIH HHS R01 CA238523
6 · The paper itself

Abstract

Several studies in chronic lymphocytic leukemia (CLL) patients have reported impaired immune cell functions, which contribute to tumor evasion and disease progression. However, studies on CLL-like monoclonal B-cell lymphocytosis (MBL) are scarce. In the study described here, we characterized the immune environment in 62 individuals with clinical MBL, 56 patients with early-stage CLL, and 31 healthy controls. Gene expression arrays and quantitative reverse transcription polymerase chain reaction were performed on RNA from CD4

Indexed as

AdultAgedAged, 80 and overB-LymphocytesCell SurvivalClone CellsCytokinesDisease ProgressionFemaleGene Expression ProfilingHumansImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionInflammationLeukemia, Lymphocytic, Chronic, B-CellLymphocyte SubsetsCytokinesImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionRNA, Neoplasm

Identifiers

PMID33421548
PMCPMC9135325
OpenAlexW3120083811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.