Evidence map›Paper›PMID 33421519›Full record

ArticleGastroenterology2021

Gastrointestinal Infection and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden.

Hamed Khalili, Jordan E Axelrad, Bjorn Roelstraete, Ola Olén, Mauro D'Amato, Jonas F Ludvigsson

Open access · bronzeAbstract read
In one paragraph

Article in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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  7. Update on the Epidemiology and Management of Microscopic Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
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4 · The record

Corrections and comments

  • Commented on by
    2021
5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Hamed KhaliliMassachusetts General Hospital, Clinical and Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts; Massachusetts General Hospital, Gastroenterology Unit, Harvard Medical School, Boston, Massachusetts; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Broad Institute of MIT and Harvard, Cambridge Massachusetts, New York, New York. Electronic address: HKHALILI@mgh.harvard.edu.
Jordan E AxelradInflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, New York.
Bjorn RoelstraeteSachs' Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden.
Ola OlénDivision of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
Mauro D'AmatoDivision of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
Jonas F LudvigssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Orebro University Hospital, Orebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
Karolinska Institutet · SEBroad Institute · USStockholm South General Hospital · SEUniversity of Nottingham · GB

Funding

Medications, the gut microbiota, and risk of microscopic colitisR01AG068390 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI KHALILI, HAMED · 2020 to 2024
$2.5M
NIA NIH HHS R01 AG068390
6 · The paper itself

Abstract

BACKGROUND AND

aimsGastrointestinal infections have been linked to changes in the composition and function of gut microbiome and development of inflammatory bowel diseases. We therefore sought to examine the relationship between gastroenteritis and risk of microscopic colitis (MC).

methodsWe conducted a case-control study of all adult patients with MC diagnosed between 1990 and 2016 in Sweden matched to up to 5 general population controls according to age, sex, calendar year, and county. Cases of MC were identified using Systematized Nomenclature of Medicine codes from the ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) study, a cohort of gastrointestinal pathology reports from all 28 pathology centers in Sweden. We used logistic regression modeling to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).

resultsThrough December of 2016, we matched 13,468 MC cases to 64,479 controls. The prevalence of previous diagnosed gastrointestinal infection was 7.5% among patients with MC, which was significantly higher than in controls (3.0%, P

conclusionIn a nationwide study, we found that gastrointestinal infection, particularly Clostridioides difficile, is associated with an increased risk of subsequent MC. This study was approved by the Regional Ethics Committee, Stockholm, Sweden (Protocol no. 2014/1287-31/4).

Indexed as

AdultAgedBacterial InfectionsCase-Control StudiesColitis, CollagenousColitis, LymphocyticColitis, MicroscopicDysbiosisFemaleGastroenteritisGastrointestinal MicrobiomeHumansMaleMiddle AgedPrevalenceRisk AssessmentCollagenous ColitisEpidemiologyLymphocytic ColitisPathogens

Identifiers

PMID33421519
PMCPMC8035297
OpenAlexW3119594163

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.