ArticleMetabolism: clinical and experimental2021
Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors.
Article in Metabolism: clinical and experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Predictive value of lipoprotein(a) in coronary artery calcification among asymptomatic cardiovascular disease subjects: A systematic review and meta-analysis.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Pooled it
- Lipoprotein(a) in Coronary Artery Disease and Aortic Stenosis: Pathophysiology, Clinical Impact, Interventional Implications and Emerging Targeted Therapies.Journal of clinical medicine · 2026Review
- The Evolving Role of Coronary Artery Imaging in Assessing Cardiovascular Risk from Lipoprotein(a).Current atherosclerosis reports · 2026Review
- Plasma metabolic profiling reveals exploratory metabolic differences in chronic coronary syndrome with coronary artery calcification.Frontiers in cardiovascular medicine · 2026Article
- Influence of Elevated Serum Lipoprotein(a) on Carotid Artery Plaque Ulceration in Patients Considered for Carotid Revascularization.Journal of atherosclerosis and thrombosis · 2026Article
- Lipoprotein(a) and plaque progression: insights from serial coronary computed tomography angiography and quantitative plaque assessment.Frontiers in cardiovascular medicine · 2026Article
- Sex-specific influence of Lipoprotein(a) levels on coronary plaque characteristics: - The COPRODUCTION Registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Research advances in current drugs targeting hyperlipidemia (Review).Molecular medicine reports · 2025Review
- The Association between Lipoprotein(a) and Coronary Artery Calcification in Elderly Patients with Diabetes: A Cross-Sectional Study.Reviews in cardiovascular medicine · 2025Article
- From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease.Journal of clinical medicine · 2024Review
- An overview of the application and potential mechanism on the triglyceride glucose index with multi-vessel coronary disease.Lipids in health and disease · 2024Review
- Review
- Clinical Diagnostic Significance of Combined Measurement of Lipoprotein(a) and Neck Circumference in Patients with Coronary Heart Disease.International journal of general medicine · 2024Article
- 2023 China Guidelines for Lipid Management.Journal of geriatric cardiology : JGC · 2023Article
- Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes.Journal of the American College of Cardiology · 2023Article
- Lipoprotein(a), Cardiovascular Events and Sex Differences: A Single Cardiological Unit Experience.Journal of clinical medicine · 2023Article
- 2023 Chinese guideline for lipid management.Frontiers in pharmacology · 2023Review
- Coronary artery calcium incidence and changes using direct plaque measurements: The MASALA study.Atherosclerosis · 2022Article
- High Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study.Journal of inflammation research · 2022Article
- Elevated serum lipoprotein(a) is significantly associated with angiographic progression of coronary artery disease.Clinical cardiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundElevated plasma lipoprotein (a) [Lp(a)] and coronary artery calcification (CAC) are established cardiovascular risk factors that correlate with each other. We hypothesized that other cardiovascular risk factors could affect their relationship.
methodsWe tested for interactions of 24 study variables related to dyslipidemia, diabetes, insulin resistance, hypertension, inflammation and coagulation with baseline Lp(a) on change in CAC volume and density over 9.5 years in 5975 Multi-Ethnic Study of Atherosclerosis (MESA) participants, free of apparent cardiovascular disease at baseline.
resultsElevated Lp(a) was associated with larger absolute increase in CAC volume (3.21 and 4.45 mm
conclusionsElevated Lp(a) was associated with an absolute increase in CAC volume, especially in participants with higher levels of selected markers of inflammation and coagulation. These results suggest Lp(a) as a potential biomarker for CAC volume progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.