Evidence map›Paper›PMID 33421452›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2021

Concurrent Anti-Glomerular Basement Membrane Antibody Disease and Membranous Nephropathy: A Case Series.

Syeda B Ahmad, Dominick Santoriello, Pietro Canetta, Andrew S Bomback, Vivette D D'Agati, Glen Markowitz, Wooin Ahn, Jai Radhakrishnan, Gerald B Appel

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In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Guideline
  2. Genes & diseases · 2027
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Syeda B AhmadDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Dominick SantorielloDepartment of Pathology, Columbia College of Physicians and Surgeons, New York, NY.
Pietro CanettaDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Andrew S BombackDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Vivette D D'AgatiDepartment of Pathology, Columbia College of Physicians and Surgeons, New York, NY.
Glen MarkowitzDepartment of Pathology, Columbia College of Physicians and Surgeons, New York, NY.
Wooin AhnDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Jai RadhakrishnanDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Gerald B AppelDivision of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. Electronic address: gba2@columbia.edu.
Columbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RATIONALE &

objectiveAnti-glomerular basement membrane (GBM) disease is a rapidly progressive glomerulonephritis which, in some instances, occurs concurrently with other diseases such as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Rarely, it also occurs with membranous nephropathy (MN). We report a series of such patients, characterizing their long-term follow up. STUDY

designCase series. SETTING &

participantsTwelve patients referred to 1 medical center between 2001 and 2019 with anti-GBM disease and MN whose clinical characteristics and course were described.

resultsPatients' ages ranged from 20 to 81 years old, and all presented with severe acute kidney injury requiring dialysis on presentation or shortly thereafter. Only 1 patient had pulmonary findings on presentation. The predominant pathology was crescentic and necrotizing glomerulonephritis with linear staining for immunoglobulin G along the GBM associated with epimembranous electron-dense immune-type deposits. All 11 patients who were tested had significant titers of anti-GBM antibodies, but only 1 of the 5 tested for phospholipase A LIMITATIONS: Incomplete testing for PLA

conclusionsIn this case series, the presentation of concurrent anti-GBM disease and MN was characterized by rapidly progressive glomerulonephritis and poor kidney outcomes. These findings suggest possible value from earlier diagnosis and the need for identification of more effective treatment regimens.

Indexed as

Acute Kidney InjuryAdultAgedAged, 80 and overAnti-Glomerular Basement Membrane DiseaseAutoantibodiesCyclophosphamideFemaleGlomerular Basement MembraneGlomerulonephritis, MembranousGlucocorticoidsHumansImmunoglobulin GImmunosuppressive AgentsMaleMiddle AgedAutoantibodiesCyclophosphamideGlucocorticoidsImmunoglobulin GImmunosuppressive AgentsPrednisoneanti-GBM diseasecase seriesconcurrent diseaseglomerular basement membrane (GBM)glomerulonephritismembranous nephropathy (MN)renal pathology

Identifiers

PMID33421452
OpenAlexW3120556707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.