Evidence map›Paper›PMID 33421352›Full record

ArticleClinical and experimental dental research2021

Interferon-γ and IL-5 associated cell-mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa.

Anna Paaso, Hanna-Mari Koskimaa, Marij J P Welters, Katja Kero, Jaana Rautava, Kari Syrjänen, Sjoerd H van der Burg, Stina Syrjänen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Development of head and neck pathology in Europe.Virchows Archiv : an international journal of pathology · 2022
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Anna PaasoDepartment of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.
Hanna-Mari KoskimaaDepartment of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.
Marij J P WeltersDepartment of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Katja KeroDepartment of Obstetrics and Gynecology, Turku University Hospital, Turku, Finland.
Jaana RautavaDepartment of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.ORCID 0000-0001-9946-2974
Kari SyrjänenDepartment of Clinical Research, Biohit Oyj, Helsinki, Finland.
Sjoerd H van der BurgDepartment of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Stina SyrjänenDepartment of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.
University of Turku · FILeiden University Medical Center · NLBiocenter Finland · FITurku University Hospital · FIUniversity of Helsinki · FI

Funding

Academy of Finland 130204/2008Academy of Finland 16438/2006Cancer Society of Southwest FinlandFinnish Cancer FoundationFinnish doctoral program in oral sciencesFinnish-Norwegian Medical FoundationGovernment Special Foundation at Turku University HospitalIda Montinin SäätiöPäivikki ja Sakari Sohlbergin SäätiöSuomen Hammas lääkäriseura Apollonia
6 · The paper itself

Abstract

objectivesNatural history of human papillomavirus (HPV) infection in the head and neck region is poorly understood, and their impact on collective HPV-specific immunity is not known. MATERIALS AND

methodsIn this study, we have performed a systematic analysis of HPV16-specific cell-mediated immunity (CMI) in 21 women with known oral and genital HPV DNA status and HPV serology (Ab) based on 6-year follow-up data. These women being a subgroup from the Finnish Family HPV Study were recalled for blood sampling to be tested for their CMI-responses to HPV16 E2, E6, and E7 peptides.

resultsThe results showed that HPV16 E2-specific lymphocyte proliferation was more prevalent in women who tested HPV16 DNA negative in oral mucosa and were either HPV16 seropositive or negative than in HPV16 DNA+/Ab+ women (p = 0.046 and p = 0.035). In addition, the HPV16 DNA-/Ab- women most often displayed E6-specific proliferation (p = 0.020). Proportional cytokine profiles indicated that oral HPV16-negative women were characterized by prominent IFN-γ and IL-5 secretion not found in women with persisting oral HPV16 (p = 0.014 and p = 0.040, respectively).

conclusionsOur results indicate that the naturally arising immune response induced by oral HPV infections displays a mixed Th1/Th2/Th17 cytokine profile while women with persisting oral HPV16 might have an impaired HPV16-specific CMI, shifted partly toward a Th2 profile, similarly as seen earlier among patients with high-grade genital HPV lesions. Thus, the lack of HPV 16 E2 and E6 specific T memory cells and Th2 cytokines might also predispose women for persistent oral HPV16 infection which might be related to the risk of cancer.

Indexed as

Interferon-gammaPapillomavirus InfectionsCytokinesFemaleHuman papillomavirus 16HumansImmunity, CellularInterleukin-5Mouth MucosaCytokinesInterferon-gammaInterleukin-5cell-mediated immunitycytokineshuman papillomavirusoral cavity

Identifiers

PMID33421352
PMCPMC8543460
OpenAlexW3120095702

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.