SynthesisBrain and behavior2021
Central nervous system manifestations in COVID-19 patients: A systematic review and meta-analysis.
Synthesis in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review.Annals of clinical and translational neurology · 2022Pooled it
- Pooled it
- Neuroimaging Findings in Patients with COVID-19: A Systematic Review and Meta-Analysis.Korean journal of radiology · 2021Pooled it
- Central nervous system manifestations in COVID-19 patients: A systematic review and meta-analysis.Brain and behavior · 2021Pooled it
- Real world research on transcranial magnetic stimulation treatment strategies for neuropsychiatric symptoms with long-COVID in Japan.Asian journal of psychiatry · 2023Trial
- Neurological, psychological, psychosocial complications of long-COVID and their management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- SARS-CoV-2 Infection Impairs Oculomotor Functions: A Longitudinal Eye-tracking Study.Journal of eye movement research · 2024Article
- Acute Necrotizing Encephalopathy in Adult Patients With COVID-19: A Systematic Review of Case Reports and Case Series.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Transcutaneous Spinal Cord Stimulation Facilitates Respiratory Functional Performance in Patients with Post-Acute COVID-19.Life (Basel, Switzerland) · 2023Article
- Neurological and Psychiatric Manifestations of Long COVID-19 and Their [Diagnostics (Basel, Switzerland) · 2023Review
- Posterior reversible encephalopathy syndrome in SARS-CoV-2 infection: A case report and review of literature.Clinical case reports · 2023Article
- COVID-19 related acute necrotizing encephalopathy presenting in the early postoperative period.Archive of clinical cases · 2023Article
- Cranial nerve involvement among COVID-19 survivors.Frontiers in neurology · 2023Article
- [Neuropathic pain and COVID-19: A silent relationship].Revista espanola de anestesiologia y reanimacion · 2022Article
- Neuropathic pain and COVID-19: A silent relationship.Revista espanola de anestesiologia y reanimacion · 2022Article
- The RAAS Axis and SARS-CoV-2: From Oral to Systemic Manifestations.Medicina (Kaunas, Lithuania) · 2022Review
- Multi-organ system involvement in coronavirus disease 2019 (COVID-19): A mega review.Journal of family medicine and primary care · 2022Review
- Review
- Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?Molecular neurobiology · 2022Review
- Gender issues during the times of COVID-19 pandemic.European journal of neurology · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAt the end of December 2019, a novel respiratory infection, initially reported in China, known as COVID-19 initially reported in China, and later known as COVID-19, led to a global pandemic. Despite many studies reporting respiratory infections as the primary manifestations of this illness, an increasing number of investigations have focused on the central nervous system (CNS) manifestations in COVID-19. In this study, we aimed to evaluate the CNS presentations in COVID-19 patients in an attempt to identify the common CNS features and provide a better overview to tackle this new pandemic.
methodsIn this systematic review and meta-analysis, we searched PubMed, Web of Science, Ovid, EMBASE, Scopus, and Google Scholar. Included studies were publications that reported the CNS features between 1 January 2020 and 20 April 2020. The data of selected studies were screened and extracted independently by four reviewers. Extracted data analyzed by using STATA statistical software. The study protocol registered with PROSPERO (CRD42020184456).
resultsOf 2,353 retrieved studies, we selected 64 studies with 11,687 patients after screening. Most of the studies were conducted in China (58 studies). The most common CNS symptom of COVID-19 was headache (8.69%, 95%CI: 6.76%-10.82%), dizziness (5.94%, 95%CI: 3.66%-8.22%), and impaired consciousness (1.90%, 95%CI: 1.0%-2.79%).
conclusionsThe growing number of studies has reported COVID-19, CNS presentations as remarkable manifestations that happen. Hence, understanding the CNS characteristics of COVID-19 can help us for better diagnosis and ultimately prevention of worse outcomes.
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