Evidence map›Paper›PMID 33421267›Full record

Trial reportEuropean journal of heart failure2021

Peripheral and pulmonary effects of inorganic nitrite during exercise in heart failure with preserved ejection fraction.

Yogesh N V Reddy, Glenn M Stewart, Masaru Obokata, Katlyn E Koepp, Barry A Borlaug

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01932606 phase2completednot on this map

Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction

TypeinterventionalSponsorBarry BorlaugRan2013 to 2014Enrolled28ConditionsHeart Disease, Heart Failure With Preserved Ejection Fraction, Exercise Intolerance, Pulmonary HypertensionArmsNitrite, Saline Placebo for Nitrite
NCT02262078 phase2completednot on this map

Acute Effects of Inhaled Sodium Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction

TypeinterventionalSponsorMayo ClinicRan2014 to 2015Enrolled26ConditionsHeart FailureArmsSodium Nitrite Inhalation Solution, Placebo
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yogesh N V Reddy *Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Glenn M Stewart *Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Masaru ObokataDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Katlyn E KoeppDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Barry A BorlaugDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · US

Funding

HL-Inorganic Nitrite to Enhance Benefits from Exercise Training in Heart Failure with preserved Ejection FractionR01HL128526 · NHLBI · MAYO CLINIC ROCHESTER · PI BORLAUG, BARRY A. · 2016 to 2019
$2.4M
NHLBI NIH HHS R01 HL128526
6 · The paper itself

Abstract

aimsTo determine whether inorganic nitrite improves peripheral and pulmonary oxygen (O METHODS AND

resultsData from two invasive, randomized, double-blind, placebo-controlled trials with matched workload exercise of inhaled and intravenous sodium nitrite were pooled for this analysis (n = 51). Directly measured O

conclusionSodium nitrite enhances skeletal muscle Dm during exercise as well as pulmonary O CLINICAL

trial registrationClinicalTrials.gov ID NCT01932606 and NCT02262078.

Indexed as

Heart FailureNitritesExercise TestExercise ToleranceHumansOxygen ConsumptionStroke VolumeNitritesExerciseHeart failureHeart failure with preserved ejection fractionInorganic nitriteSkeletal muscle

Identifiers

PMID33421267
OpenAlexW3120778718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.