Evidence map›Paper›PMID 33420907›Full record

ReviewCurrent genetics2021

Model systems for studying polyphosphate biology: a focus on microorganisms.

Alix Denoncourt, Michael Downey

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 50 citations in OpenAlex.

  1. The roles and synthesis of inorganic polyphosphate inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. The microbial phosphorus cycle in aquatic ecosystems.Nature reviews. Microbiology · 2025
    Review
  7. Antioxidants (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Ppn2 Polyphosphatase Improves the Ability ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  10. mSphere · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. bioRxiv : the preprint server for biology · 2023
    Article
  17. Reentrant DNA shells tune polyphosphate condensate size.bioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alix DenoncourtDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, K1H 8M5, Canada.
Michael DowneyDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, K1H 8M5, Canada. mdowne2@uottawa.ca.ORCID http://orcid.org/0000-0002-5234-6666
University of Ottawa · CA

Funding

CIHR PJT-148722
6 · The paper itself

Abstract

Polyphosphates (polyP) are polymers of inorganic phosphates joined by high-energy bonds to form long chains. These chains are present in all forms of life but were once disregarded as 'molecular fossils'. PolyP has gained attention in recent years following new links to diverse biological roles ranging from energy storage to cell signaling. PolyP research in humans and other higher eukaryotes is limited by a lack of suitable tools and awaits the identification of enzymatic players that would enable more comprehensive studies. Therefore, many of the most important insights have come from single-cell model systems. Here, we review determinants of polyP metabolism, regulation, and function in major microbial systems, including bacteria, fungi, protozoa, and algae. We highlight key similarities and differences that may aid in our understanding of how polyP impacts cell physiology at a molecular level.

Indexed as

Models, BiologicalBacteriaCyanobacteriaEnergy MetabolismFungiHumansPolyphosphatesSignal TransductionPolyphosphatesAcidocalcisomesDdp1Model systemspolyPPolyphosphatePPKPpn1Ppn2PPXPpx1VacuoleVTCVtc4

Identifiers

PMID33420907
OpenAlexW3121006590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.