Trial reportJournal of cancer survivorship : research and practice2021
Social support as a moderator of healthcare adherence and distress in long-term hematopoietic cell transplantation survivors.
Trial report in Journal of cancer survivorship : research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00799461 (INSPIRE), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INSPIRE: An Internet-based RCT for Long-term Survivors of Hematopoietic Stem Cell Transplantation
Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Self-Efficacy for Symptom Management in Long-Term Adult Hematopoietic Stem Cell Survivors.Transplantation and cellular therapy · 2022Trial
- The role of social engagement and support in the association between combined caregiver-cancer survivor status and depressive symptoms.The Gerontologist · 2026Article
- Patient-reported outcomes in chronic GVHD: instruments, clinical utility, and survivorship integration.Journal of patient-reported outcomes · 2026Review
- Psychological Prehabilitation for People Undergoing Autologous Stem Cell Transplant: A Qualitative Study.Psycho-oncology · 2026Article
- Beyond medication: Understanding child and caregiver perspectives on multifaceted adherence in pediatric hematopoietic stem cell transplantation.Palliative & supportive care · 2026Article
- Assessing Social Determinants of Health in Transplantation and CAR-T Recipients: Expert Panel Recommendations from the Survivorship Special Interest Group of ASTCT.Transplantation and cellular therapy · 2025Review
- The Caregiver Paradigm in Hematopoietic Cell Transplant: Current and Future Directions.Transplantation and cellular therapy · 2025Review
- Burden, resources, and needs of patients with severe graft-versus-host disease - A qualitative study.Palliative & supportive care · 2025Article
- Social support in a large general population sample over the course of six years.Scientific reports · 2025Article
- An investigation of the factors influencing college students' rural cultural preservation behaviors in the context of rural cultural revitalization: a hybrid SEM-ANN approach.Frontiers in psychology · 2025Article
- "A second birthday"? Experiences of persons with multiple sclerosis treated with autologous hematopoietic stem cell transplantation-a qualitative interview study.Frontiers in neurology · 2024Article
- Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Health-Related Quality of Life Outcomes in Older Hematopoietic Cell Transplantation Survivors.Transplantation and cellular therapy · 2023Article
- It Takes a Village: The Importance of Social Support after Hematopoietic Stem Cell Transplantation, a Qualitative Study.Transplantation and cellular therapy · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTreatment with hematopoietic cell transplantation (HCT) has potentially severe effects on physical and psychosocial functioning. Poor social support has been linked with physical morbidity and mortality as well as psychological distress in HCT survivors. This study tested a theory-driven hypothesis that social support buffers adverse effects of health stressors of comorbidities and graft-versus-host disease (cGVHD) on distress and adherence to recommended healthcare among long-term HCT survivors.
methodsThis cross-sectional study analyzed baseline data from a randomized controlled trial in adult survivors 3-18 years post-HCT. Data included medical records and patient-reported outcomes including cancer and treatment distress (CTXD), healthcare adherence (HCA), comorbidity index, cGVHD, ENRICHD Social Support Instrument (ESSI), Social Activity Log, and Health Self-Efficacy. We tested hypothesized models for HCA and CTXD using blocked hierarchical linear regressions.
resultsAmong the 781 HCT survivors completing baseline assessment, 38% had > 3 comorbidities, 8% had moderate-severe cGVHD, 30% reported low social support, 30% reported elevated distress, and 49% reported low healthcare adherence. Social support and self-efficacy were directly related to both adherence and distress. Regression models supported the hypothesized moderated relationships for distress but not for healthcare adherence.
conclusionsThe two tested models confirm that the health stressors of comorbidities and cGVHD are moderated by better social support and self-efficacy in their associations with lower distress but without moderating effects for healthcare adherence. IMPLICATIONS FOR CANCER SURVIVORS: Social support and self-efficacy confer protective benefits on healthcare adherence and psychological distress. Interventions are needed that focus on maintaining social networks or finding new networks if necessary. CLINICAL TRIAL REGISTRATION NUMBER: NCT00799461.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.