ArticleJournal of neuro-oncology2021
Resected WHO grade I meningioma and predictors of local control.
Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biomarkers for prognosis of meningioma patients: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Time-dependent prognostic value of automated Ki67 assessment and its integration with molecular risk profiling in WHO grade 2 meningioma.Acta neuropathologica communications · 2026Article
- Quantification of Ki-67 labeling index in pediatric brain tumor immunohistochemistry images.Journal of neuropathology and experimental neurology · 2026Article
- Attention-based deep learning network for predicting World Health Organization meningioma grade and Ki-67 expression based on magnetic resonance imaging.European radiology · 2026Article
- Article
- Development of a Machine Learning Algorithm for the Prediction of WHO Grade 1 Meningioma Recurrence.Cureus · 2025Article
- A multi-modal deep learning model for prediction of Ki-67 for meningiomas using pretreatment MR images.NPJ precision oncology · 2025Article
- Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution.Science advances · 2024Article
- Functional precision medicine assay for recurrent meningioma: a proof of principle. Illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- A comprehensive correlation of the KI-67 proliferation index to patient´s, imaging and tumor features and its value in predicting long-term course of patients with newly diagnosed intracranial meningiomas.Neurosurgical review · 2024Article
- Predicting meningioma grades and pathologic marker expression via deep learning.European radiology · 2024Article
- Predictors of recurrence after surgical resection of parafalcine and parasagittal meningiomas.Acta neurochirurgica · 2023Article
- Location pattern of recurrence of fully resected grade 1 meningiomas.Acta neurochirurgica · 2023Article
- MRI-based machine learning models predict the malignant biological behavior of meningioma.BMC medical imaging · 2023Article
- Signaling pathways in brain tumors and therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- Article
- The applicability of established clinical and histopathological risk factors for tumor recurrence during long-term postoperative care in meningioma patients.Neurosurgical review · 2022Article
- Primary intraosseous meningioma with subcutaneous and dural invasion: A case report and literature review.Frontiers in surgery · 2022Article
- Machine Learning Using Multiparametric Magnetic Resonance Imaging Radiomic Feature Analysis to Predict Ki-67 in World Health Organization Grade I Meningiomas.Neurosurgery · 2021Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDespite optimal surgical resection, meningiomas may recur, with increasing grade and the degree of resection being predictive of risk. We hypothesize that an increasing Ki67 correlates with a higher risk of recurrence of resected WHO grade I meningiomas.
methodsThe study population consisted of patients with resected WHO grade 1 meningiomas in locations outside of the base of skull. Digitally scanned slides stained for Ki67 were analyzed using automatic image analysis software in a standardized fashion.
resultsRecurrence was observed in 53 (17.7%) of cases with a median follow up time of 25.8 months. Ki67 ranged from 0 to 30%. Median Ki67 was 5.1% for patients with recurrence and 3.5% for patients without recurrence. In unadjusted analyses, high Ki-67 (≥ 5 vs. < 5) vs. ≥ 5) was associated with over a twofold increased risk of recurrence (13.1% vs. 27% respectively; HR 2.1731; 95% CI [1.2534, 3.764]; p = 0.006). After Adjusting for patient or tumor characteristics, elevated Ki-67 remained significantly correlated with recurrence. Grade 4 Simpson resection was noted in 71 (23.7%) of patients and it was associated with a significantly increased risk of recurrence (HR 2.56; 95% CI [1.41, 4.6364]; p = 0.002).
conclusionsWHO grade 1 meningiomas exhibit a significant rate of recurrence following resection. While Ki-67 is not part of the WHO grading criteria of meningiomas, a value greater than 5% is an independent predictor for increased risk of local recurrence following surgical resection.
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