ReviewBiogerontology2021
Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders.
Review in Biogerontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Effects of Fractionated Low Dose Ionizing Radiation on Cellular Senescence in Mouse Lung Tissue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Environmental Carcinogenesis as a Stochastic Evolutionary Failure of Senescence-Control Systems.Cells · 2026Review
- Kilovoltage Energy Significantly Enhances the Therapeutic Efficacy of Low-Dose Radiation in a 3xTg-AD Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2026Article
- Investigation of cellular senescence in the mouse liver caused by low dose fractionated X-ray therapy.Radiation oncology (London, England) · 2026Article
- Insights into the Impact of Low-Dose Ionizing Radiation on Neurodegenerative Disease Progression in In Vivo Models.International journal of molecular sciences · 2026Review
- Dose-Dependent Dual Effects of Gradient Ionizing Radiation on Neurocognition.International journal of molecular sciences · 2026Review
- Low-Dose radiation risk in medicine: a look at risk models, challenges, and future prospects.Zeitschrift fur medizinische Physik · 2025Review
- Reduction in Severe, Chronic Mid-Back Pain Following Correction of Sagittal Thoracic Spinal Alignment Using Chiropractic BioPhysicsHealthcare (Basel, Switzerland) · 2025Article
- Vorinostat, a potential hormetin, extends lifespan and enhances stress resistance via the SKN-1 pathway in Caenorhabditis elegans.Biogerontology · 2025Article
- Environmental epigenomics and the human imprintome.Environmental epigenetics · 2025Article
- Meta-Analysis of the Impact of Low-Dose Ionizing Radiation on Mortality and Progression of Heart Disease in the General Patient Population: Insights from Hormesis Theory in Cardiology.Journal of clinical medicine · 2024Review
- The untapped potential of cell culture in disentangling insect-microbial relationships.Microbiome research reports · 2024Review
- Dose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation.Epigenetics · 2023Article
- Assessment of radiation level and potential risk to public living around major hospitals in central and western Bangladesh.Heliyon · 2023Article
- Correlative links between natural radiation and life expectancy in the US population.Biogerontology · 2022Article
- Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach.Molecules (Basel, Switzerland) · 2022Review
- Assessment of Systemic Toxicity, Genotoxicity, and Early Phase Hepatocarcinogenicity of Iron (III)-Tannic Acid Nanoparticles in Rats.Nanomaterials (Basel, Switzerland) · 2022Article
- Potential role of gut microbiota-LCA-INSR axis in high fat-diet-induced non-alcoholic fatty liver dysfunction: From perspective of radiation variation.Current research in food science · 2022Article
- Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts.International journal of molecular sciences · 2021Review
- Questioning the Linear No-Threshold Model (LNT): Lessons From Hiroshima/Nagasaki and Fukushima.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting hormesis through exposure to low-dose ionizing radiation (LDIR). Radiation-induced longevity hormesis has been repeatedly reported in invertebrate models such as C. elegans, Drosophila and flour beetles and in vertebrate models including guinea pigs, mice and rabbits. On the contrary, suppressing natural background radiation was repeatedly found to cause detrimental effects in protozoa, bacteria and flies. We also discussed here the possibility of clinical use of LDIR, predominantly for age-related disorders, e.g., Alzheimer's disease, for which no remedies are available. There is accumulating evidence that LDIR, such as those commonly used in X-ray imaging including computer tomography, might act as a hormetin. Of course, caution should be exercised when introducing new medical practices, and LDIR therapy is no exception. However, due to the low average residual life expectancy in old patients, the short-term benefits of such interventions (e.g., potential therapeutic effect against dementia) may outweigh their hypothetical delayed risks (e.g., cancer). We argue here that assessment and clinical trials of LDIR treatments should be given priority bearing in mind the enormous economic, social and ethical implications of potentially-treatable, age-related disorders.
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