ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Associations Between Potentially Modifiable and Nonmodifiable Risk Factors and Gait Speed in Middle- and Older-Aged Adults: Results From the Canadian Longitudinal Study on Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03020381 (Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study
Who cites it
12 citing papers in PubMed.
- Five-year disability trajectories and associated factors among adults aging with HIV in the Ontario HIV Treatment Network Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Walking Speed and Hand Grip Strength as Predictors of Hypertension Risk in Older Adults: The Impact of Insulin Resistance.Geriatrics & gerontology international · 2025Article
- Long-Term Blood Pressure Variability and Physical Performance in Older Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2025Observational
- Losing Ground Following Community Exercise Programme Closures: A Qualitative Descriptive Study of the Impact of COVID-19 Related Pandemic Restrictions on Exercise Participation, Physical Activity, and Health of Older Adults With Balance and Mobility Limitations.Physiotherapy Canada. Physiotherapie Canada · 2025Article
- Association between education and walking speed: counterfactual mediation analysis in favor of a motor reserve hypothesis.American journal of epidemiology · 2025Article
- Article
- Gait speed after mild stroke/transient ischemic attack was associated with long-term adverse outcomes: A cohort study.Annals of clinical and translational neurology · 2024Article
- Changes in Physical Performance among Community-Dwelling Older Adults in Six Years.International journal of environmental research and public health · 2023Article
- Mediation Analyses of the Role of Apathy on Motoric Cognitive Outcomes.International journal of environmental research and public health · 2022Article
- Active With Whom? Examining the Social Context of Physical Activity in Individuals After Stroke and Their Partners.Frontiers in public health · 2021Article
- Observational
- Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundGait speed is a strong predictor of morbidity and mortality in older adults. Understanding the factors associated with gait speed and the associated adverse outcomes will inform mitigation strategies. We assessed the potentially modifiable and nonmodifiable factors associated with gait speed in a large national cohort of middle and older-aged Canadian adults.
methodsWe examined cross-sectional baseline data from the Canadian Longitudinal Study on Aging (CLSA) Comprehensive cohort. The study sample included 20 201 community-dwelling adults aged 45-85 years. The associations between sociodemographic and anthropometric factors, chronic conditions, and cognitive, clinical, and lifestyle factors and 4-m usual gait speed (m/s) were estimated using hierarchical multivariable linear regression.
resultsThe coefficient of determination, R 2, of the final regression model was 19.7%, with 12.9% of gait speed variability explained by sociodemographic and anthropometric factors, and nonmodifiable chronic conditions and 6.8% explained by potentially modifiable chronic conditions, cognitive, clinical, and lifestyle factors. Potentially modifiable factors significantly associated with gait speed include cardiovascular conditions (unstandardized regression coefficient, B = -0.018; p < .001), stroke (B = -0.025; p = .003), hypertension (B = -0.007; p = .026), serum Vitamin D (B = 0.004; p < .001), C-reactive protein (B = -0.005; p = .005), depressive symptoms (B = -0.003; p < .001), physical activity (B = 0.0001; p < .001), grip strength (B = 0.003; p < .001), current smoking (B = -0.026; p < .001), severe obesity (B = -0.086; p < .001), and chronic pain (B = -0.008; p = .018).
conclusionsThe correlates of gait speed in adulthood are multifactorial, with many being potentially modifiable through interventions and education. Our results provide a life-course-perspective framework for future longitudinal assessments risk factors affecting gait speed.
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