Evidence map›Paper›PMID 33420779›Full record

ArticleGigaScience2021

Identifying the effect of vancomycin on health care-associated methicillin-resistant Staphylococcus aureus strains using bacteriological and physiological media.

Akanksha Rajput, Saugat Poudel, Hannah Tsunemoto, Michael Meehan, Richard Szubin, Connor A Olson, Yara Seif, Anne Lamsa, Nicholas Dillon, Alison Vrbanac and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GigaScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Akanksha RajputDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Saugat PoudelDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Hannah TsunemotoDivision of Biological Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Michael MeehanCollaborative Mass Spectrometry Innovation Center, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Richard SzubinDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Connor A OlsonDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Yara SeifDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Anne LamsaDivision of Biological Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Nicholas DillonDepartment of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92023, USA.
Alison VrbanacDepartment of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92023, USA.
Joseph SugieDivision of Biological Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Samira DaheshDepartment of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92023, USA.
Jonathan M MonkDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Rob KnightDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Joe PoglianoDivision of Biological Sciences, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Victor NizetSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Adam M FeistDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
Bernhard O PalssonDepartment of Bioengineering, University of California, 9500 Gilman Dr, La Jolla, CA 92093, USA.
University of California San Diego · USNovo Nordisk Foundation · DKScripps Institution of Oceanography · US

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
Safety and Dose Optimization of High-Dose Anakinra in Kawasaki DiseaseP50HD090259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAPPARELLI, EDMUND VINCENT, NIZET, VICTOR · 2019 to 2020
$1.4M
NIAID NIH HHS U01 AI124316NICHD NIH HHS P50 HD090259
6 · The paper itself

Abstract

backgroundThe evolving antibiotic-resistant behavior of health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) USA100 strains are of major concern. They are resistant to a broad class of antibiotics such as macrolides, aminoglycosides, fluoroquinolones, and many more.

findingsThe selection of appropriate antibiotic susceptibility examination media is very important. Thus, we use bacteriological (cation-adjusted Mueller-Hinton broth) as well as physiological (R10LB) media to determine the effect of vancomycin on USA100 strains. The study includes the profiling behavior of HA-MRSA USA100 D592 and D712 strains in the presence of vancomycin through various high-throughput assays. The US100 D592 and D712 strains were characterized at sub-inhibitory concentrations through growth curves, RNA sequencing, bacterial cytological profiling, and exo-metabolomics high throughput experiments.

conclusionsThe study reveals the vancomycin resistance behavior of HA-MRSA USA100 strains in dual media conditions using wide-ranging experiments.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsDelivery of Health CareHumansMicrobial Sensitivity TestsVancomycinVancomycin

Identifiers

PMID33420779
PMCPMC7794652
OpenAlexW3120947023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.