SynthesisBiological trace element research2021
Relationship Between Selenium in Human Tissues and Breast Cancer: a Meta-analysis Based on Case-Control Studies.
Synthesis in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Selenium nanoparticles for breast cancer: mechanisms, delivery strategies, and translational challenges.Frontiers in oncology · 2026Review
- Selenium Nutritional Status Assessment in Chinese Adult Females: Results from the China Nutrition and Health Surveillance in 2015.Nutrients · 2025Article
- Modification Effects of Homologous Recombination Repair Gene Polymorphisms on the Associations Between Urinary Metals and Breast Cancer Risk.Biological trace element research · 2025Article
- Cohort profile: Guangzhou breast cancer study (GBCS).European journal of epidemiology · 2024Article
- Sodium Selenite Induces Autophagy and Apoptosis in Cervical Cancer Cells via Mitochondrial ROS-Activated AMPK/mTOR/FOXO3a Pathway.Antioxidants (Basel, Switzerland) · 2024Article
- Micronutrient Status and Breast Cancer: A Narrative Review.International journal of molecular sciences · 2024Review
- Article
- Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer.Biological trace element research · 2022Article
- Article
- The TSH/Thyroid Hormones Axis and Breast Cancer.Journal of clinical medicine · 2022Review
- The Role of Selenium in Pathologies: An Updated Review.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Breast cancer is a common malignant tumor in women, and the anti-cancer effect of selenium (Se) is recognized. This meta-analysis was designed to determine the relationship between selenium levels in human tissue and breast cancer risk. Literatures published before August 2020 were systematically screened through PubMed, Web of Science, Scopus, and Elsevier. The related publication quality was evaluated by the Newcastle-Ottawa scale. We used random effect models for calculation and conducted sensitivity analysis and evaluation of publication bias. We identified 18 case-control studies, including 3374 women diagnosed with breast cancer and 3582 healthy controls. The results showed that the difference between the case group and the control group was - 0.53 μg/l [95%CI - 0.72 to - 0.34] (P < 0.001). Subgroup analysis showed a serum difference of - 1.14 μg/l [95%CI - 1.70 to - 0.58] (P < 0.001). The value of plasma was - 0.21 μg/l [95% CI - 0.37 to - 0.04] (P = 0.014). The value of toenail was - 0.21 μg/l [95% CI - 0.38 to - 0.03] (P = 0.021). In contrast, selenium levels in hair were not significantly associated with breast cancer risk. In the case-control studies, it was observed that selenium level in human tissues was negatively correlated with the risk of breast cancer, which may improve the understanding of the effects of selenium on human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.