Evidence map›Paper›PMID 33420659›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

Divergence of acetate uptake in proinflammatory and inflammation-resolving macrophages: implications for imaging atherosclerosis.

Selim Demirdelen, Philip Z Mannes, Ali Mubin Aral, Joseph Haddad, Steven A Leers, Delphine Gomez, Sina Tavakoli

Open access · greenAbstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  4. Article
  5. Review
  6. Use ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  7. Imaging Immunometabolism in Atherosclerosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Review
  8. Review
  9. Molecular imaging
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Selim DemirdelenDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Philip Z MannesDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Ali Mubin AralDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Joseph HaddadDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Steven A LeersDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Delphine GomezDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Sina TavakoliDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA. sit23@pitt.edu.
University of Pittsburgh · USUPMC Health System · US

Funding

Epigenetic control of smooth muscle cell phenotype during microvascular remodelingR01HL146465 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Delphine Gomez · 2019 to 2026
$3.4M
A Molecular Imaging Approach to Immuno-Metabolic Characterization of Vessel Wall MacrophagesK08HL144911 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAVAKOLI, SINA · 2019 to 2023
$813k
NHLBI NIH HHS K08 HL144911NHLBI NIH HHS R01 HL146465
6 · The paper itself

Abstract

backgroundMetabolic divergence of macrophages polarized into different phenotypes represents a mechanistically relevant target for non-invasive characterization of atherosclerotic plaques using positron emission tomography (PET). Carbon-11 ( METHODS AND

resultsHistological correlates of

conclusionsAcetate uptake by macrophages diverges upon proinflammatory and inflammation-resolving stimulation, which may be exploited for immunometabolic characterization of atherosclerosis.

Indexed as

AtherosclerosisPlaque, AtheroscleroticAcetatesAnimalsHumansInflammationInterferon-gammaInterleukin-4LipopolysaccharidesMacrophagesMiceTomography, X-Ray ComputedAcetatesInterferon-gammaInterleukin-4LipopolysaccharidesAcetateatherosclerosisimagingmacrophage polarizationmetabolism

Identifiers

PMID33420659
PMCPMC8935477
OpenAlexW3118716698

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.