ArticleBrain topography2021
Resting-State Functional Connectivity and Brain Network Abnormalities in Depressive Patients with Suicidal Ideation.
Article in Brain topography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Differences in white matter structural networks in family risk of major depressive disorder and suicidality: A connectome analysis.Journal of affective disorders · 2026Article
- Association between EEG microstate and cognitive function in depressed patients with and without suicidal ideation.BMC psychiatry · 2025Observational
- Longitudinal analysis of brain functional connectivity and its association with clinical assessment in depressed patients using resting state fMRI.Scientific reports · 2025Article
- Psychoneuroimmunoendocrinological and neuroanatomical basis of suicidal behavior: potential therapeutic strategies with a focus on transcranial magnetic stimulation (TMS).Brain, behavior, & immunity - health · 2025Article
- Biomarkers of Suicidal Ideation in Depression: Insights From VMHC Analysis and Machine Learning.Neuropsychiatric disease and treatment · 2025Article
- The efficacy and neuroplasticity of Tuina combined with repetitive transcranial magnetic stimulation in the treatment of post-stroke depression: study protocol for a single-center, randomized, controlled trial.Frontiers in neurology · 2025Article
- Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care.Translational psychiatry · 2024Article
- Neuroimaging studies in major depressive disorder with suicidal ideation or behaviour among Chinese patients: implications for neural mechanisms and imaging signatures.General psychiatry · 2024Review
- Connectomics-based resting-state functional network alterations predict suicidality in major depressive disorder.Translational psychiatry · 2023Article
- Altered dynamic brain activity and functional connectivity in thyroid-associated ophthalmopathy.Human brain mapping · 2023Article
- Potential neuropsychological mechanism involved in the transition from suicide ideation to action - a resting-state fMRI study implicating the insula.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies.Frontiers in psychiatry · 2023Review
- Effects of transcranial combined with peripheral repetitive magnetic stimulation on limb spasticity and resting-state brain activity in stroke patients.Frontiers in human neuroscience · 2023Article
- Suicidal Ideation Is Associated With Reduced Functional Connectivity and White Matter Integrity in Drug-Naïve Patients With Major Depression.Frontiers in psychiatry · 2022Article
- Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2022Article
- Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study.Frontiers in human neuroscience · 2021Article
- Mood disorders disrupt the functional dynamics, not spatial organization of brain resting state networks.NeuroImage. Clinical · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our study aimed to investigate whether changes in brain function measured with functional magnetic resonance imaging (fMRI) can be detected among individuals with depressive disorders and suicidal ideation. The association between depression severity and brain images is also discussed. Our study recruited 111 participants in three groups: 35 depressive patients with suicidal ideation (SI), 32 depressive patients without suicidal ideation (NS), and 44 healthy controls (HCs). All participants were scanned using 3T MRI to obtain resting-state functional images, and functional connectivity (FC), amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and graph theoretical analysis (GTA) were performed. We found functional activity differences, such as the hippocampus and thalamus, in the SI group compared with the NS group. We also concluded lower activity in the thalamus and cuneus regions were related to suicidal ideation. We also found several functional connectivity of the brain areas, such as hippocampus, cuneus, and frontal regions, in the SI group correlated with Hamilton Depression Rating Scale (HAM-D) and Hospital Anxiety and Depression Scale (HADS). A graph theoretical analysis (GTA) and network-based statistical (NBS) analysis revealed different topological organization and slightly better local segregation of the brain network in healthy participants compared with those in depressive patients with suicidal ideation. We suggest that brain functional connectivity may be affected in depressive patients with suicidal ideation.
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