SynthesisMolecular psychiatry2021
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Epigenome-wide association study meta-analysis of wellbeing.Clinical epigenetics · 2026Pooled it
- Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use.Molecular psychiatry · 2024Pooled it
- Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- DNA methylation in peripheral tissues and left-handedness.Scientific reports · 2022Pooled it
- Article
- Child and adolescent internalizing and externalizing traits, and epigenetic summary scores: A scoping review.Biological psychology · 2025Article
- Intergenerational transmission of complex traits and the offspring methylome.Molecular psychiatry · 2025Article
- Association of exposure to second-hand smoke during childhood with blood DNA methylation.Environment international · 2025Article
- Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study.BMC genomics · 2024Article
- A preliminary investigation of epigenome-wide DNA methylation and temperament during infancy.Developmental psychobiology · 2024Article
- A multi-omics data analysis workflow packaged as a FAIR Digital Object.GigaScience · 2024Article
- Cigarette smoke exposure accelerates AML progression in FLT3-ITD models.Blood advances · 2023Article
- Integrative Multi-omics Analysis of Childhood Aggressive Behavior.Behavior genetics · 2023Article
- Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control.Genome biology · 2023Article
- Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort.Neuroscience applied · 2023Article
- The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment.Epigenomics · 2022Article
- Differences inFrontiers in genetics · 2022Article
- Associations of age, sex, sexual abuse, and genotype with monoamine oxidase a gene methylation.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Identical twins carry a persistent epigenetic signature of early genome programming.Nature communications · 2021Article
- Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
89 authors at 20 institutions in 13 countries.
Jenny van DongenDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. j.van.dongen@vu.nl.ORCID http://orcid.org/0000-0003-2063-8741
Fiona A HagenbeekDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8773-0430
Matthew SudermanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Peter J RoetmanCurium-LUMC, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Oegstgeest, The Netherlands.ORCID http://orcid.org/0000-0002-6495-962X
Karen SugdenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Andreas G ChiocchettiDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe-Universität, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-7329-9985
Khadeeja IsmailInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0334-6480
Rosa H MulderInstitute of Education and Child Studies, Leiden University, Leiden, The Netherlands.
Jonathan D HaffertyDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Mark J AdamsDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3599-6018
Rosie M WalkerCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1060-4479
Stewart W MorrisCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Jari LahtiTurku Institute for Advanced Studies, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Leanne K KüpersUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-9850-5215
Georgia EscaramisCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.ORCID http://orcid.org/0000-0002-5416-3177
Silvia AlemanyISGlobal, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7925-6767
Marc Jan BonderDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-8431-3180
Mandy MeijerDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-9307-0643
Hill F IpDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1991-5019
Rick JansenDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3333-6737
Bart M L BaselmansDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Priyanka ParmarCenter for Life Course Health Research, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.
Estelle LowryCenter for Life Course Health Research, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.ORCID http://orcid.org/0000-0002-4655-416X
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0003-1080-4339
Lea SirignanoDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-7989-5833
Tabea S SendDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4867-9465
Juulia JylhäväDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Yunzhang WangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pashupati Prasad MishraDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.
Olivier F ColinsCurium-LUMC, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Oegstgeest, The Netherlands.ORCID http://orcid.org/0000-0001-9532-2544
David L CorcoranCenter for Genomic and Computational Biology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-7460-9247
Richie PoultonDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-1052-4583
Jonathan MillUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0003-1115-3224
Eilis HannonUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0001-6840-072X
Louise ArseneaultSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2938-2191
Tellervo KorhonenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Eero VuoksimaaInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Janine F FelixGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
Marian J Bakermans-KranenburgClinical Child & Family Studies, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7763-0711
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Darina CzamaraDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany.ORCID http://orcid.org/0000-0001-7381-904X
Elisabeth BinderDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany.ORCID http://orcid.org/0000-0001-7088-6618
Eva CorpeleijnUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Juan R GonzalezISGlobal, Barcelona, Spain.ORCID http://orcid.org/0000-0003-3267-2146
Regina GrazulevicieneDepartment of Environmental Sciences, Vytautas Magnus University, K. Donelaicio str. 58, 44248, Kaunas, Lithuania.ORCID http://orcid.org/0000-0002-0210-8053
Kristine B GutzkowDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Jorunn EvandtDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Marina VafeiadiDepartment of Social Medicine, University of Crete, Heraklion, Greece.ORCID http://orcid.org/0000-0002-6143-7172
Marieke KleinDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8784-5679
Dennis van der MeerNORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-0466-386X
Lannie LigthartDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6570-3319
BIOS Consortium
Cornelis KluftGood Biomarker Sciences, Leiden, The Netherlands.
Gareth E DaviesAvera Institute for Human Genetics, 3720 W. 69th Street, Sioux Falls, SD, 57108, USA.
Christian HakulinenDepartment of Psychology and logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Liisa Keltikangas-JärvinenDepartment of Psychology and logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Barbara FrankeDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4375-6572
Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe-Universität, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0001-9676-4782
Kerstin KonradUniversity Hospital, RWTH Aachen, Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Aachen, Germany.ORCID http://orcid.org/0000-0001-9039-2615
Amaia HervasHospital Universitario Mutua de Terrassa, Child and Adolescent Mental Health Service, Barcelona, Spain.
Aranzazu Fernández-RivasBasurto University Hospital, Psychiatric Service, Osakidetza, Bilbao, Spain.
Agnes VetroSzeged University, Department of Pediatrics and Pediatrics health center, Child and Adolescent Psychiatry, Szeged, Hungary.
Olli RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.ORCID http://orcid.org/0000-0002-2555-4427
Robert VermeirenCurium-LUMC, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Oegstgeest, The Netherlands.
Timo StrandbergHelsinki University Central Hospital, Geriatrics, Helsinki, Finland.
Katri RäikkönenDepartment of Psychology and logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Harold SniederUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1949-2298
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
Michael DeuschleDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2452-1500
Jordi SunyerISGlobal, Barcelona, Spain.
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Jaakko KaprioInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Miina OllikainenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3661-7400
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Henning TiemeierDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4395-1397
Marinus H van IJzendoornDepartment of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1144-454X
Caroline ReltonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Martine VrijheidISGlobal, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7090-1758
Sylvain SebertCenter for Life Course Health Research, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.ORCID http://orcid.org/0000-0001-6681-6983
Marjo-Riitta JarvelinCenter for Life Course Health Research, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.ORCID http://orcid.org/0000-0002-2149-0630
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Kathryn L EvansCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7884-5877
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Meike BartelsDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9667-7555
Dorret I BoomsmaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
University Medical Center Groningen · NLLeiden University Medical Center · NLUniversity of Helsinki · FIVrije Universiteit Amsterdam · NLErasmus MC · NLUniversity of Edinburgh · GBDuke University · USHeidelberg University · DEMaastricht University · NLRadboud University Nijmegen · NLGoethe University Frankfurt · DEUniversitat Pompeu Fabra · ESAvera Health · USHammersmith Hospital · GBHarvard University · USHelsinki University Hospital · FIKarolinska Institutet · SENorwegian Institute of Public Health · NOTampere University of Applied Sciences · FIUniversity of Bristol · GB
Funding
Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0MIs mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5MInternational Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2MNeuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8MGENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8MAGING &VASCULAR DISEASE ROLE OF GLYCATIONR01AG009453 · NIA · PICOWER INSTITUTE FOR MEDICAL RESEARCH · PI VLASSARA, HELEN · 1991 to 2007
$2.6MMetabolomic and Epigenomic Mechanisms in Developmental Overnutrition.R01DK103246 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2014 to 2018
$2.2MAdolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2MCholesterol metabolism pathway: Cognitive change and Alzheimer's disease riskR01AG028555 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI REYNOLDS, CHANDRA A · 2007 to 2010
$1.1MEuropean Research Council 230374European Research Council 268479Medical Research Council G1002190Medical Research Council MC_UU_00011/5Medical Research Council MR/J000914/1Medical Research Council MR/K013807/1Medical Research Council MR/M008924/1Medical Research Council MR/P005918/1Medical Research Council MR/R005176/1MRF_ C0396NIAAA NIH HHS R01 AA012502NIA NIH HHS R01 AG009453NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG028555NIA NIH HHS R01 AG032282NICHD NIH HHS R01 HD077482NIDDK NIH HHS R01 DK103246NIEHS NIH HHS N01 ES075558NIMH NIH HHS R01 MH062873NINDS NIH HHS U01 NS047537Wellcome Trust 088806Wellcome Trust 102215
Abstract
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10
Indexed as
DNA MethylationEpigenomeAdolescentAdultAgedAggressionChildChild, PreschoolCpG IslandsEpigenesis, GeneticGenome-Wide Association StudyHumansLongevityMiddle AgedYoung Adult
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