Evidence map›Paper›PMID 33420297›Full record

ArticleScientific reports2021

Bioavailable fluoride in calcium-containing dentifrices.

Peiyan Shen, James R Fernando, Yi Yuan, Glenn D Walker, Coralie Reynolds, Eric C Reynolds

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

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  11. Remineralization Effect of Calcium Glycerophosphate in Fluoride Mouth Rinse on Eroded Human Enamel: AnJournal of International Society of Preventive & Community Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Peiyan ShenCentre for Oral Health Research, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC, 3010, Australia.
James R FernandoCentre for Oral Health Research, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC, 3010, Australia.
Yi YuanCentre for Oral Health Research, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC, 3010, Australia.
Glenn D WalkerCentre for Oral Health Research, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC, 3010, Australia.
Coralie ReynoldsCentre for Oral Health Research, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC, 3010, Australia.
Eric C ReynoldsCentre for Oral Health Research, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Carlton, Melbourne, VIC, 3010, Australia. e.reynolds@unimelb.edu.au.
University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium added to dentifrices can complex with fluoride ions to reduce intra-oral bioavailability and therefore efficacy in preventing dental caries. Six commercially available dentifrices containing different types of calcium and fluoride were analyzed for total and bioavailable fluoride levels by adding 10 g of dentifrice to 30 mL of distilled deionized water and mixing vigorously for 1 min to simulate toothbrushing. One milliliter of the dentifrice/water slurry was immediately centrifuged and the supernatant removed for bioavailable fluoride analysis and the mixed slurry prior to centrifugation used for total fluoride analysis using a modified microdiffusion method. The concentration of fluoride was determined using a fluoride ion-selective electrode calibrated with internal fluoride standards. All the dentifrices had similar total fluoride concentrations to those indicated on their labels (94% to 105%). However, only one dentifrice that contained calcium in the form of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) had almost 100% (97%) of fluoride in bioavailable form. The other dentifrices contained calcium carbonate and they exhibited significantly (p < 0.001) lower bioavailable fluoride levels (27% to 61%), through the generation of poorly soluble fluoride phases. The saliva biomimetic CPP, as CPP-ACP, in a dentifrice stabilised calcium and fluoride ions to maintain fluoride's bioavailability.

Identifiers

PMID33420297
PMCPMC7794534
OpenAlexW3120453258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.