ArticleCommunications biology2021
Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Modulation of the Sporulation Dynamics in the Plant-Probiotic Bacillus velezensis 83 via Carbon and Quorum-Sensing Metabolites.Probiotics and antimicrobial proteins · 2025Article
- Dynamic regulation of iturin production via reconstructing the quorum-sensing system ComQXPA in Bacillus subtilis.World journal of microbiology & biotechnology · 2025Article
- Bacillus subtilis ensures high spore quality in competition with Salmonella Typhimurium via the SigB-dependent pathway.The ISME journal · 2025Article
- Molecular mechanisms and applications of natural transformation in bacteria.Frontiers in microbiology · 2025Review
- Development of a Microbioreactor forMicromachines · 2024Article
- Cinnamaldehyde Targets the LytTR DNA-Binding Domain of the Response Regulator AgrA to Attenuate Biofilm Formation of Listeria monocytogenes.Microbiology spectrum · 2023Article
- Large-Scale Identification of Known and Novel RRNPP Quorum-Sensing Systems by RRNPP_Detector Captures Novel Features of Bacterial, Plasmidic, and Viral Coevolution.Molecular biology and evolution · 2023Article
- eDNA Provides a Scaffold for Autoaggregation ofMicroorganisms · 2023Article
- Impact ofMicrobiology spectrum · 2022Article
- Andrographolide Inhibits Biofilm and Virulence inMolecules (Basel, Switzerland) · 2022Article
- Systems view of Bacillus subtilis pellicle development.NPJ biofilms and microbiomes · 2022Article
- Evolution of two-component quorum sensing systems.Access microbiology · 2022Article
- Modeling the time course of ComX: towards molecular process control for Bacillus wild-type cultivations.AMB Express · 2021Article
- Influence of B. subtilis 3NA mutations in spo0A and abrB on surfactin production in B. subtilis 168.Microbial cell factories · 2021Article
- Surfactin Facilitates Horizontal Gene Transfer inFrontiers in microbiology · 2021Article
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Authors and funding
6 authors.
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Abstract
Bacterial quorum sensing (QS) is based on signal molecules (SM), which increase in concentration with cell density. At critical SM concentration, a variety of adaptive genes sharply change their expression from basic level to maximum level. In general, this sharp transition, a hallmark of true QS, requires an SM dependent positive feedback loop, where SM enhances its own production. Some communication systems, like the peptide SM-based ComQXPA communication system of Bacillus subtilis, do not have this feedback loop and we do not understand how and if the sharp transition in gene expression is achieved. Based on experiments and mathematical modeling, we observed that the SM peptide ComX encodes the information about cell density, specific cell growth rate, and even oxygen concentration, which ensure power-law increase in SM production. This enables together with the cooperative response to SM (ComX) a sharp transition in gene expression level and this without the SM dependent feedback loop. Due to its ultra-sensitive nature, the ComQXPA can operate at SM concentrations that are 100-1000 times lower than typically found in other QS systems, thereby substantially reducing the total metabolic cost of otherwise expensive ComX peptide.
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