Evidence map›Paper›PMID 33420261›Full record

ArticleScientific reports2021

Gamma-radiated immunosuppressed tumor xenograft mice can be a new ideal model in cancer research.

Hamid Khodayari, Saeed Khodayari, Solmaz Khalighfard, Arash Tahmasebifar, Mahboubeh Tajaldini, Amirhoushang Poorkhani, Hassan Nikoueinejad, Gholam Ali Hamidi, Hassan Nosrati, Mohammad Reza Kalhori and 1 more

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The Hematopoietic Function of Medicinal Wine Maoji Jiu Revealed in Blood Deficiency Model Rats.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Hamid Khodayari *Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Saeed Khodayari *Radiation Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Solmaz KhalighfardCancer Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Arash TahmasebifarIschemic Disorder Center, Golestan University of Medical Sciences, Gorgan, Iran.
Mahboubeh TajaldiniIschemic Disorder Center, Golestan University of Medical Sciences, Gorgan, Iran.
Amirhoushang PoorkhaniIschemic Disorder Center, Golestan University of Medical Sciences, Gorgan, Iran.
Hassan NikoueinejadNephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Gholam Ali HamidiPhysiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Hassan NosratiRadiation Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza KalhoriMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Ali Mohammad AlizadehCancer Research Center, Tehran University of Medical Sciences, Tehran, Iran. aalizadeh@sina.tums.ac.ir.
Tehran University of Medical Sciences · IRGolestan University of Medical Sciences · IRKashan University of Medical Sciences · IRBaqiyatallah University of Medical Sciences · IRKermanshah University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor xenograft models can create a high capacity to study human tumors and discover efficient therapeutic approaches. Here, we aimed to develop the gamma-radiated immunosuppressed (GIS) mice as a new kind of tumor xenograft model for biomedical studies. First, 144 mice were divided into the control and treated groups exposed by a medical Cobalt-60 apparatus in 3, 4, and 5 Gy based on the system outputs. Then, 144 BALB/c mice were divided into four groups; healthy, xenograft, radiation, and radiation + xenograft groups. The animals in the xenograft and radiation + xenograft groups have subcutaneously received 3 × 10

Indexed as

Disease Models, AnimalAnimalsAntigens, DifferentiationBreast NeoplasmsCobalt RadioisotopesCytokinesFemaleGamma RaysHeterograftsHumansImmunosuppression TherapyMCF-7 CellsMiceMice, Inbred BALB CSpleenTumor BurdenAntigens, DifferentiationCobalt-60Cobalt RadioisotopesCytokines

Identifiers

PMID33420261
PMCPMC7794493
OpenAlexW3120249986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.