ArticleScientific reports2021
Thermoresponsive motor behavior is mediated by ring neuron circuits in the central complex of Drosophila.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 16 citations in OpenAlex.
- Estimating orientation in natural scenes: A spiking neural network model of the insect central complex.PLoS computational biology · 2024Article
- Vimo - Visual Analysis of Neuronal Connectivity Motifs.IEEE transactions on visualization and computer graphics · 2023Article
- Ring neurons in the Drosophila central complex act as a rheostat for sensory modulation of aging.PLoS biology · 2023Article
- Comparative analysis of temperature preference behavior and effects of temperature on daily behavior in 11 Drosophila species.Scientific reports · 2022Article
- Functional analysis of enhancer elements regulating the expression of the Drosophila homeodomain transcription factor DRx by gene targeting.Hereditas · 2021Article
- Genetic Transsynaptic Techniques for Mapping Neural Circuits inFrontiers in neural circuits · 2021Review
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Insects are ectothermal animals that are constrained in their survival and reproduction by external temperature fluctuations which require either active avoidance of or movement towards a given heat source. In Drosophila, different thermoreceptors and neurons have been identified that mediate temperature sensation to maintain the animal's thermal preference. However, less is known how thermosensory information is integrated to gate thermoresponsive motor behavior. Here we use transsynaptic tracing together with calcium imaging, electrophysiology and thermogenetic manipulations in freely moving Drosophila exposed to elevated temperature and identify different functions of ellipsoid body ring neurons, R1-R4, in thermoresponsive motor behavior. Our results show that warming of the external surroundings elicits calcium influx specifically in R2-R4 but not in R1, which evokes threshold-dependent neural activity in the outer layer ring neurons. In contrast to R2, R3 and R4d neurons, thermogenetic inactivation of R4m and R1 neurons expressing the temperature-sensitive mutant allele of dynamin, shibire
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