ArticleScientific reports2021
Impacts of sleep on the characteristics of dental biofilm.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 31 citations in OpenAlex.
- Bidirectional Relationship Between Dental Diseases and Sleep Disturbances in Pediatric Patients.Clinical and experimental dental research · 2025Review
- Associations Between Oral Microbiota Pathogens and Elevated Depressive and Anxiety Symptoms in Men.Depression and anxiety · 2025Article
- Synergistic effects of arginine and fluoride on human dental biofilm control.Journal of dentistry · 2024Article
- An extensive description of the microbiological effects of silver diamine fluoride on dental biofilms using an oral in situ model.Scientific reports · 2022Article
- Establishment of novel in vitro culture system with the ability to reproduce oral biofilm formation on dental materials.Scientific reports · 2021Article
- Impact of sleep on the microbiome of oral biofilms.PloS one · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental biofilm present on the tooth surface is associated with oral diseases, such as dental caries and periodontal disease. Because bacterial numbers rapidly increase in saliva during sleep, oral care before sleeping is recommended for the prevention of chronic oral diseases. However, temporal circadian changes in the quantity and quality of dental biofilms are poorly understood. This study aimed to investigate the impacts of sleeping on dental biofilm amounts and compositions by using an in situ model. The use of this in situ model enabled us to investigate dental biofilm formed in the oral cavity and to perform a quantitative analysis. Subjects began wearing oral splints in the morning or before sleeping, and biofilm samples were collected at 8, 16, and 24 h after the subjects began wearing oral splints; these samples were then used in various experiments. No significant changes in the numbers of biofilm-forming bacteria were caused by sleep. However, the relative abundances of genera related to periodontitis (i.e., Fusobacterium and Prevotella) increased after awakening. In conclusion, the numbers of biofilm-forming bacteria were not affected by sleep, and the abundances of obligate anaerobes increased after sleep. This research may aid in defining efficacious preventive oral care.
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Registered trials
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