Evidence map›Paper›PMID 33420211›Full record

ArticleScientific reports2021

Respiratory chain components are required for peptidoglycan recognition protein-induced thiol depletion and killing in Bacillus subtilis and Escherichia coli.

Chun-Kai Yang, Des R Kashyap, Dominik A Kowalczyk, David Z Rudner, Xindan Wang, Dipika Gupta, Roman Dziarski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Disparate Effects of Two Clerodane Diterpenes of Giant Goldenrod (International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chun-Kai YangIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Des R KashyapIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Dominik A KowalczykIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
David Z RudnerDepartment of Microbiology, Harvard Medical School, Boston, MA, 02115, USA.
Xindan WangDepartment of Biology, Indiana University, Bloomington, IN, 47405, USA.
Dipika GuptaIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Roman DziarskiIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA. rdziar@iun.edu.
Indiana University Northwest · USHarvard University · USIndiana University Bloomington · USIndiana University School of Medicine

Funding

Chromosome Dynamics in Bacillus SubtillsR01GM086466 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2009 to 2021
$4.2M
Antibacterial activity of peptidoglycan recognition proteinsR01AI120962 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI DZIARSKI, ROMAN · 2016 to 2019
$1.6M
NIAID NIH HHS R01 AI120962NIGMS NIH HHS R01 GM086466
6 · The paper itself

Abstract

Mammalian peptidoglycan recognition proteins (PGRPs or PGLYRPs) kill bacteria through induction of synergistic oxidative, thiol, and metal stress. Tn-seq screening of Bacillus subtilis transposon insertion library revealed that mutants in the shikimate pathway of chorismate synthesis had high survival following PGLYRP4 treatment. Deletion mutants for these genes had decreased amounts of menaquinone (MK), increased resistance to killing, and attenuated depletion of thiols following PGLYRP4 treatment. These effects were reversed by MK or reproduced by inhibiting MK synthesis. Deletion of cytochrome aa

Indexed as

Electron TransportBacillus subtilisCarrier ProteinsEscherichia coliImmunity, InnateMetabolic Networks and PathwaysOxygen ConsumptionShikimic AcidSulfhydryl CompoundsTranscriptomeCarrier Proteinspeptidoglycan recognition proteinShikimic AcidSulfhydryl Compounds

Identifiers

PMID33420211
PMCPMC7794252
OpenAlexW3119326124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.