ArticleScientific reports2021
Direct entry of cell-penetrating peptide can be controlled by maneuvering the membrane curvature.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Molecular dynamics simulations unveil the aggregation patterns and salting out of polyarginines at zwitterionic POPC bilayers in solutions of various ionic strengths.Computational and structural biotechnology journal · 2024Article
- Beyond Transduction: Anti-Inflammatory Effects of Cell Penetrating Peptides.Molecules (Basel, Switzerland) · 2024Review
- Cell-Penetrating Peptide-Mediated Biomolecule Transportation in Artificial Lipid Vesicles and Living Cells.Molecules (Basel, Switzerland) · 2024Review
- Negative lipid membranes enhance the adsorption of TAT-decorated elastin-like polypeptide micelles.Biophysical journal · 2024Article
- Antifungal Activity and Molecular Mechanisms of Copper Nanoforms againstNanomaterials (Basel, Switzerland) · 2023Article
- Cell-Penetrating Milk-Derived Peptides with a Non-Inflammatory Profile.Molecules (Basel, Switzerland) · 2023Article
- Review
- Stealthy Player in Lipid Experiments? EDTA Binding to Phosphatidylcholine Membranes Probed by Simulations and Monolayer Experiments.The journal of physical chemistry. B · 2023Article
- Ionic Strength and Solution Composition Dictate the Adsorption of Cell-Penetrating Peptides onto Phosphatidylcholine Membranes.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Experimental Investigations on the Conductance of Lipid Membranes under Differential Hydrostatic Pressure.Membranes · 2022Article
- Volumetric Semantic Instance Segmentation of the Plasma Membrane of HeLa Cells.Journal of imaging · 2021Article
- Predicting cell-penetrating peptides using machine learning algorithms and navigating in their chemical space.Scientific reports · 2021Article
- Effect of Vesicle Size on the Cytolysis of Cell-Penetrating Peptides (CPPs).International journal of molecular sciences · 2020Article
- Key Process and Factors Controlling the Direct Translocation of Cell-Penetrating Peptide through Bio-Membrane.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A biomembrane's role is to be a barrier for interior cytosol from an exterior environment to execute the cell's normal biological functions. However, a water-soluble peptide called cell-penetrating peptide (CPP) has been known for its ability to directly penetrate through the biomembranes into cells (cytolysis) without perturbating cell viability and expected to be a promising drug delivery vector. Examples of CPP include peptides with multiple arginine units with strong cationic properties, which is the key to cytolysis. Here we show the conclusive evidence to support the mechanism of CPP's cytolysis and way to control it. The mechanism we proposed is attributed to biomembrane's physicochemical nature as lamellar liquid crystal (Lα). Cytolysis occurs as the temporal and local dynamic phase transitions from Lα to an undulated lamellar with pores called Mesh
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