ArticleScientific reports2021
Compositions and antimicrobial properties of binary ZnO-CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 95 citations in OpenAlex.
- Synthesis, Characterization, and Multifunctional Bioactivity of ZnO/CuO@Amoxicillin Nanocomposites: A Synergistic Nano-Platform With Potent Antioxidant, Anti-Inflammatory, Antidiabetic, and Anti-Cholinesterase Activities.Chemistry & biodiversity · 2026Article
- From traditional uses to biochemical evidence: phytochemical diversity and bioactivities of Calotropis gigantea-a comprehensive update since 2013.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Eco-friendly synthesis of ZnO nanostructures from yeast strains isolated from kombucha and beetroot kwass for antimicrobial thin film applications.Bioprocess and biosystems engineering · 2026Article
- Metal Oxide Nanocomposites as Next-Generation Antimicrobial Agents Against Oral Cariogenic Pathogens: Mechanistic Actions of Ag-ZnO and Cu-ZnO onMaterials (Basel, Switzerland) · 2026Article
- Optimized green zinc oxide/chitosan/amoxicillin nanocomposite against Pseudomonas aeruginosa.Applied microbiology and biotechnology · 2026Article
- Evaluation of the biological activities of Bacillus cereus-synthesized titanium dioxide nanoparticles.Applied microbiology and biotechnology · 2026Article
- Characterization of Bacillus atrophaeus Strain from the Composite Material Surface in Arctic Conditions and Its Sensitivity to CuO Nanoparticles.Current microbiology · 2026Article
- Eco-friendly fabrication of Fe₃O₄/α-MnO₂ nanocomposites using Pentas schimperiana leaf extract for enhanced biomedicinal and environmental applications.Scientific reports · 2026Article
- Article
- Chitosan and L-histidine coated biofunctional TiO₂ composite with enhanced ROS-mediated antimicrobial and anticancer efficacy for biomedical applications.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- The potential of Eco-friendly synthesis of multifunctional ZnO-CuO nanocomposites using Mentha longifolia extract for their biomedical applications.Journal of materials science. Materials in medicine · 2025Article
- Silver-coated Zea mays L. nanocatalyst for efficient Azo dye photodegradation and antimicrobial applications.Scientific reports · 2025Article
- Exploring the antibacterial properties of ZnO nanorods-CuO nanoflowers: a mode of action approach.RSC advances · 2025Article
- Facile phyto-mediated synthesis of ternary CuO/MnScientific reports · 2025Article
- HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction ofHeliyon · 2025Article
- Synthesis and characterization of innovative GA@Ag-CuO nanocomposite with potent antimicrobial and anticancer properties.Scientific reports · 2025Article
- Gamma-irradiated copper-based metal organic framework nanocomposites for photocatalytic degradation of water pollutants and disinfection of some pathogenic bacteria and fungi.BMC microbiology · 2024Article
- Green synthesis of trimetallic CuO/Ag/ZnO nanocomposite using Ziziphus spina-christi plant extract: characterization, statistically experimental designs, and antimicrobial assessment.Scientific reports · 2024Article
- Investigation of antibacterial and anticancer activities of copper, aluminum and nickel doped zinc sulfide nanoparticles.Scientific reports · 2024Article
- Psidium guajava-mediated green synthesis of Fe-doped ZnO and Co-doped ZnO nanoparticles: a comprehensive study on characterization and biological applications.Bioprocess and biosystems engineering · 2024Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO-CuO nanocomposites from C. gigantea against non-MDR (Staphylococcus aureus and Escherichia coli) and MDR (Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin-resistant S. aureus) skin pathogens. Scanning electron microscopy and transmission electron microscopy revealed the size and shape of B3Z1C sample. Results of X-ray powder diffraction, energy-dispersive spectroscopy, FTIR and UV-Vis spectroscopy analyses confirmed the presence of mixed nanoparticles (i.e., zinc oxide, copper oxide, carbon and calcium) and the stabilising phytochemical agents of plant (i.e., phenol and carbonyl). Antimicrobial results showed that carbon and calcium decorated binary ZnO-CuO nanocomposites with compositions of 75 wt% of ZnO and 25 wt% CuO (B3Z1C) was a strong bactericidal agent with the MBC/MIC ratio of ≤ 4 and ≤ 2 for non-MDR and MDR pathogens, respectively. A significant non-MDR zone of inhibitions were observed for BZC by Kirby-Bauer disc-diffusion test. Further time-kill observation revealed significant fourfold reduction in non-MDR pathogen viable count after 12 h study period. Further molecular studies are needed to explain the biocidal mechanism underlying B3Z1C potential.
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