ArticleNature communications2021
Spread spectrum SERS allows label-free detection of attomolar neurotransmitters.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- A Review of SERS-Based Bacterial Detection from Nanomaterials to Integrated Clinical Platforms.Biosensors · 2026Review
- Raman Peaks Feature-Based Machine Learning for Raman Spectroscopy Quantification of Inorganic Pollutants.Sensors (Basel, Switzerland) · 2026Article
- Gold- or Silver-Nanoparticle SERS Platforms for Plasma-Based Diagnostics and AI-Driven Analysis.Sensors (Basel, Switzerland) · 2026Review
- A High-Density Nanoporous SERS Substrate Prepared by Facile One-Step Anodization for P-Hydroxybenzoic Acid Detection.Sensors (Basel, Switzerland) · 2026Article
- Review
- Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis.Light, science & applications · 2025Review
- SERS Cheminformatics: Opportunities for Data-Driven Discovery and Applications.ACS central science · 2025Review
- SERS-guided photodynamic therapy: pioneering strategies in advanced cancer diagnosis and treatment.Discover nano · 2025Review
- Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light-Driven Nanozyme Sensor Array and Machine Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Depression among Tibetan residents in the Southeastern region of Qinghai-Tibet plateau: a cross-sectional study.Scientific reports · 2025Article
- Optical biosensors for diagnosing neurodegenerative diseases.Npj biosensing · 2025Review
- Paeoniflorin ameliorates depressive behaviours by modulating microbiota-gut-brain axis functions.General psychiatry · 2025Article
- Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer.Light, science & applications · 2024Article
- Binding of Glutamic Acid to Silver and Gold Nanoparticles Investigated by Surface-Enhanced Raman Spectroscopy.Biosensors · 2024Article
- Tunable Nanoislands Decorated Tapered Optical Fibers Reveal Concurrent Contributions in Through-Fiber SERS Detection.ACS photonics · 2024Article
- Potential of plasmonics and nanoscale light-matter interactions for the next generation of optical neural interfaces.Neurophotonics · 2024Article
- Emerging technologies toward the integration of multiple functionalities on non-planar implantable neurophotonics probes.Neurophotonics · 2024Article
- Plasmonic Gold Prism Array for Digital Surface-Enhanced Raman Spectroscopy Sensing.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles.Cell research · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quantitative label-free detection of neurotransmitters provides critical clues in understanding neurological functions or disorders. However, the identification of neurotransmitters remains challenging for surface-enhanced Raman spectroscopy (SERS) due to the presence of noise. Here, we report spread spectrum SERS (ss-SERS) detection for the rapid quantification of neurotransmitters at the attomolar level by encoding excited light and decoding SERS signals with peak autocorrelation and near-zero cross-correlation. Compared to conventional SERS measurements, the experimental result of ss-SERS shows an exceptional improvement in the signal-to-noise ratio of more than three orders of magnitude, thus achieving a high temporal resolution of over one hundred times. The ss-SERS measurement further allows the attomolar SERS detection of dopamine, serotonin, acetylcholine, γ-aminobutyric acid, and glutamate without Raman reporters. This approach opens up opportunities not only for investigating the early diagnostics of neurological disorders or highly sensitive biomedical SERS applications but also for developing low-cost spectroscopic biosensing applications.
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