ArticleOpen heart2021
IMPULSE: the impact of gender on the presentation and management of aortic stenosis across Europe.
Article in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Mitral Regurgitation after TAVR: Sex Differences and Low-Flow Low-Gradient Aortic Stenosis.JACC. Advances · 2026Article
- A Review of Sex Differences in Patients with Aortic Stenosis: A Focus on Diagnostic and Treatment Differences, a Narrative Review.Journal of clinical medicine · 2026Review
- Left ventricular changes in moderate aortic stenosis in women compared to men.European heart journal. Imaging methods and practice · 2026Article
- Sex Differences Among Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Single-Center Observational Study.Echocardiography (Mount Kisco, N.Y.) · 2026Observational
- Sex-Related Differences in the Management and Outcomes of Patients Across the Spectrum of Aortic Stenosis.Journal of the American Heart Association · 2026Article
- Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study.JACC. Advances · 2026Article
- Specificities of Aortic Stenosis in Women - From Diagnosis to Management.Saudi medical journal · 2026Review
- Sex Differences in the Effects of Perioperative Rehabilitation on Postoperative Pulmonary Complications After Cardiac Valve Surgery: A Prespecified Subgroup Analysis of the PORT Randomized Trial.International journal of women's health · 2026Article
- Gender Matters: A State-of-the-Art Review of Transcatheter Structural Interventions in Older Women Vs Men.JACC. Advances · 2025Article
- Global, regional, and national burden of nonrheumatic calcific aortic valve disease based on GBD study 2021.Scientific reports · 2025Article
- Sex Differences in Reverse Left Ventricular Remodeling in Patients Who Underwent Transcatheter Aortic Valve Replacement in a Chinese Population.Reviews in cardiovascular medicine · 2025Article
- Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women.Structural heart : the journal of the Heart Team · 2025Review
- Sex-Associated Disparities in Surgical and Percutaneous Management of Aortic Stenosis With Severe Features: Retrospective Analysis From the National Readmission Database.Journal of the American Heart Association · 2025Article
- Longitudinal Outcomes of Patients with Aortic Stenosis Stratified by Sex: An Asian Perspective.Journal of cardiovascular development and disease · 2025Article
- Sex-related differences in prosthesis-patient mismatch following aortic valve replacement with the edwards intuity valve system.Frontiers in cardiovascular medicine · 2025Article
- Sex-related disparities in aortic stenosis from disease awareness to treatment: a state-of-the-art review.Journal of thoracic disease · 2024Review
- Sex-related differences among patients undergoing surgical aortic valve replacement-a propensity score matched study.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Sex-Specific Considerations in Degenerative Aortic Stenosis for Female-Tailored Transfemoral Aortic Valve Implantation Management.Journal of the American Heart Association · 2022Review
- Sex differences in aortic stenosis: Identification of knowledge gaps for sex-specific personalized medicine.American heart journal plus : cardiology research and practice · 2022Article
- The Evolution of Pulmonary Hypertension and Its Prognostic Implications Post-TAVI-Single Center Experience.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
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Authors and funding
26 authors at 20 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThere is an increasing awareness of gender-related differences in patients with severe aortic stenosis and their outcomes after surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI).
methodsData from the IMPULSE registry were analysed. Patients with severe aortic stenosis (AS) were enrolled between March 2015 and April 2017 and stratified by gender. A subgroup analysis was performed to assess the impact of age.
resultsOverall, 2171 patients were enrolled, and 48.0% were female. Women were characterised by a higher rate of renal impairment (31.7 vs 23.3%; p<0.001), were at higher surgical risk (EuroSCORE II: 4.5 vs 3.6%; p=0.001) and more often in a critical preoperative state (7.0vs 4.2%; p=0.003). Men had an increased rate of previous cardiac surgery (9.4 vs 4.7%; p<0.001) and a reduced left ventricular ejection fraction (4.9 vs 1.3%; p<0.001). Concomitant mitral and tricuspid valve disease was substantially more common among women. Symptoms were highly prevalent in both women and men (83.6 vs 77.3%; p<0.001). AVR was planned in 1379 cases. Women were more frequently scheduled to undergo TAVI (49.3 vs 41.0%; p<0.001) and less frequently for SAVR (20.3 vs 27.5%; p<0.001).
conclusionsThe present data show that female patients with severe AS have a distinct patient profile and are managed in a different way to males. Gender-based differences in the management of patients with severe AS need to be taken into account more systematically to improve outcomes, especially for women.
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