ArticleCancer genomics & proteomics
Noncoding RNAs Serve as the Deadliest Universal Regulators of all Cancers.
Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Review
- Review
- Noncoding RNAs evolutionarily extend animal lifespan.Global medical genetics · 2025Article
- Conceptual breakthroughs of the long noncoding RNA functional system and its endogenous regulatory role in the cancerous regime.Exploration of targeted anti-tumor therapy · 2024Review
- Ambiguous genes due to aligners and their impact on RNA-seq data analysis.Scientific reports · 2023Article
- Article
- Article
- Distinctive functional regime of endogenous lncRNAs in dark regions of human genome.Computational and structural biotechnology journal · 2022Article
- Noncoding RNAs endogenously rule the cancerous regulatory realm while proteins govern the normal.Computational and structural biotechnology journal · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous cancer drivers have been identified, but they are specific to a given cancer type and condition; universal cancer drivers and universal cancer mechanisms still remain largely unclear. Here, we identified the deadliest universal drivers for all cancers via developing algorithms to analyze massive RNAseqs and clinical data from The Cancer Genome Atlas (TCGA). In general, noncoding RNAs primarily serve as the most important inducers and suppressors for all types of cancers. In particular, pseudogenes are primary inducers, and specifically the antisense RNA RP11-335K5.2 serves as the most universal cancerous driver, independently of the cancer type and condition. Therefore, noncoding RNAs, instead of proteins as conventionally thought, primarily drive cancer, which establishes a novel field for future cancer research and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.