Evidence map›Paper›PMID 33419860›Full record

ArticleJournal for immunotherapy of cancer2021

Letter to the editor: Checking the pulse of adoptive cell therapy for solid tumors. Thoughts from the abstracts submitted to the 35th Annual Meeting of the Society for the Immunotherapy of Cancer (SITC 2020).

Martina Markovska, Francesco Marincola

Abstract readLetter
In one paragraph

Article in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Martina MarkovskaImmunology, Radboud Universiteit, Nijmegen, Gelderland, The Netherlands.
Francesco MarincolaScience, Refuge Biotechnologies, Menlo Park, California, USA fmarincola@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive cell therapy (ACT) for the treatment of solid malignancies has not met yet the success of hematological malignancies. This is due to additional roadblocks peculiar to its deployment for the former application. While T-cell fitness stands as a prerequisite for all purposes of ACT, selection of optimal tumor-specific antigens, efficient trafficking to neoplastic tissues, and overcoming immune exclusion and/or suppression are challenges pertaining predominantly to solid malignancies. To gain insights about the current interest on the subject in both academia and industry, we surveyed a snapshot of topical activities and checked the pulse of the field by reviewing content extracted from 94 abstracts submitted, under the subject "cellular therapies", to the 35th Anniversary Annual Meeting of the Society for the Immunotherapy of Cancer.

Indexed as

Adoptive TransferAntigens, NeoplasmCongresses as TopicHumansNeoplasmsTumor MicroenvironmentAntigens, Neoplasmcell engineeringchimeric antigendrug evaluationimmunotherapylymphocytespreclinicalreceptorstumor-infiltrating

Identifiers

PMID33419860
PMCPMC7798779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.