ArticleScience immunology2021
Tissue-resident CD4
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it, 209 citations in OpenAlex.
- Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026Pooled it
- Immune signatures underlying post-acute COVID-19 lung sequelae.Science immunology · 2021Trial
- Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals.The Journal of clinical investigation · 2020Trial
- Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study.BMC medical informatics and decision making · 2026Article
- Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies.Immunological reviews · 2026Review
- CD8MedComm · 2026Review
- Harnessing mucosal immunity for protective vaccines.Nature reviews. Immunology · 2026Review
- PD-1 Inhibits CD4+ TRM-Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Seasonal influenza mRNA vaccine induces stronger innate and comparable or better adaptive responses than licensed inactivated vaccines.NPJ vaccines · 2026Article
- Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza.The Journal of experimental medicine · 2026Article
- HIF-1αImmunity · 2026Article
- Immunological memory to vaccines.Immunity · 2026Review
- Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth.Cancer immunology research · 2026Article
- Dual induction of tissue-resident T and B cell immunity for broad influenza protection with a nanofiber-VLP vaccine.Journal of nanobiotechnology · 2026Article
- The B cell receptor-mTOR signaling axis restricts the accumulation of lung tissue-resident memory B cells after influenza infection.Science immunology · 2026Article
- An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals.Cell reports. Medicine · 2026Article
- The role of T cells in influenza infection and vaccination.Virologica Sinica · 2026Review
- CD27 and ICOS as Targets of PD-1/PD-L1 Signaling to Regulate Resident Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Exercise and tissue-resident memory T cells: from circulating numbers to spatial immune remodeling.Frontiers in immunology · 2026Review
- Evolving role of CD8Frontiers in immunology · 2026Review
80 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byT2021
Authors and funding
14 authors at 7 institutions in 2 countries.
Young Min SonDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2978-8703
In Su CheonDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Yue WuDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3667-2960
Chaofan LiDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Zheng WangDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-6002-5299
Xiaochen GaoDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Yao ChenVersiti Blood Research Institute, Milwaukee, WI 53213, USA.
Yoshimasa TakahashiDepartment of Immunology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
Yang-Xin FuDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0002-4809-825X
Alexander L DentDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7226-8936
Mark H KaplanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2923-8245
Justin J TaylorVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.ORCID 0000-0001-9718-2901
Weiguo CuiVersiti Blood Research Institute, Milwaukee, WI 53213, USA.
Jie SunDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA. sun.jie@mayo.edu.ORCID 0000-0002-2347-4511
Mayo Clinic · USIndiana University School of MedicineFred Hutch Cancer Center · USMedical College of Wisconsin · USNational Institute of Infectious Diseases · JPSouthwestern Medical Center · USVersiti Blood Center of Wisconsin · US
Funding
The role of PU.1 in T helper cell heterogeneityR01AI057459 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 2005 to 2025
$8.2MHost cellular network governing the development of post SARS-CoV-2 tissue sequelaeR01AI147394 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$4.7MMolecular regulation of protective CD8 immunity against influenza infectionR01AI112844 · NIAID · UNIVERSITY OF VIRGINIA · PI SUN, JIE · 2015 to 2024
$4.5MElucidating the roles of alveolar macrophage inflammation and selfrenewal during influenza infectionR01AG069264 · NIA · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$3.5MPhenotypic, Functional and Transcriptional Heterogeneity in T Cell ExhaustionR01AI148403 · NIAID · VERSITI WISCONSIN, INC. · PI WEIGUO CUI · 2020 to 2026
$3.1MRoles of tissue-resident helper T cells in mucosal immunity against influenzainfectionR01AI154598 · NIAID · UNIVERSITY OF VIRGINIA · PI SUN, JIE · 2020 to 2024
$2.9MThe Cellular and Transcriptional Control of CD8 T Cell Functional Adaptation to Chronic VirusesR01AI125741 · NIAID · VERSITI WISCONSIN, INC. · PI CUI, WEIGUO · 2016 to 2020
$2.1MSimultaneously boosting both humoral and cellular immunity following vaccinationR01AG047156 · NIA · MAYO CLINIC ROCHESTER · PI SUN, JIE · 2015 to 2019
$1.6MNIAID NIH HHS R01 AI057459NIAID NIH HHS R01 AI112844NIAID NIH HHS R01 AI125741NIAID NIH HHS R01 AI147394NIAID NIH HHS R01 AI148403NIAID NIH HHS R01 AI154598NIA NIH HHS R01 AG047156NIA NIH HHS R01 AG069264
Abstract
Much remains unknown about the roles of CD4
Indexed as
Immunity, MucosalAnimalsBasic Helix-Loop-Helix ProteinsDisease Models, AnimalFemaleHomeodomain ProteinsHumansInfluenza A virusInfluenza, HumanLungMaleMemory B CellsMemory T CellsMiceMice, TransgenicProto-Oncogene Proteins c-bcl-6Basic Helix-Loop-Helix ProteinsBcl6 protein, mouseBhlhe40 protein, mouseHomeodomain ProteinsProto-Oncogene Proteins c-bcl-6
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.