ArticleCancer prevention research (Philadelphia, Pa.)2021
Functional Common and Rare
Riyue Bao, Anita Ng, Mark Sasaki, Myvizhi Esai Selvan, Alyna Katti, Hyesan Lee, Lei Huang, Andrew D Skol, Cinzia Lavarino, Hector Salvador and 4 more
Open access · bronzeAbstract read
In one paragraphArticle in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors at 6 institutions in 2 countries.
Riyue Bao *Hillman Cancer Center, UPMC, Pittsburgh, Pennsylvania.
Anita Ng *The Feinstein Institute for Medical Research, Manhasset, New York.
Mark SasakiDepartment of Pediatrics, The University of Chicago, Chicago, Illinois.
Myvizhi Esai SelvanThe Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-4640-5727 Hyesan LeeDepartment of Pediatrics, The University of Chicago, Chicago, Illinois.
Lei HuangDepartment of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai, New York, New York.
Andrew D SkolDepartment of Pediatrics, The University of Chicago, Chicago, Illinois.
Cinzia LavarinoPediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0002-9630-3676 Hector SalvadorPediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu, Barcelona, Spain.
Robert J KleinThe Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0003-3539-5391 Zeynep H GümüşThe Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-7364-2202 Kenan OnelThe Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York. kenan.onel@mssm.edu.ORCID 0000-0002-2021-6250 University of Chicago · USUniversity of Illinois Chicago · USHospital Sant Joan de Déu Barcelona · ESFeinstein Institute for Medical Research · USIcahn School of Medicine at Mount Sinai · USUniversity of Pittsburgh · US
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0MUCCRC--ETIOLOGY OF TREATMENT-INDUCED SECONDARY LEUKEMIAP01CA040046 · NCI · UNIVERSITY OF CHICAGO · PI LARSON, RICHARD A · 1985 to 2012
$19.9MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MWhole Genome Sequencing to Discover Familial Myeloma Risk GenesR01CA167824 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LIPKIN, STEVEN M, OFFIT, KENNETH · 2012 to 2016
$1.9MPrognostic Genetic Biomarkers for CancerR21CA129045 · NCI · UNIVERSITY OF CHICAGO · PI ONEL, KENAN · 2007 to 2008
$338kNCI NIH HHS P01 CA040046NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA167824NCI NIH HHS R21 CA129045NIH HHS S10 OD026880
6 · The paper itselfAbstract
We investigated a Spanish and Catalan family in which multiple cancer types tracked across three generations, but for which no genetic etiology had been identified. Whole-exome sequencing of germline DNA from multiple affected family members was performed to identify candidate variants to explain this occurrence of familial cancer. We discovered in all cancer-affected family members a single rare heterozygous germline variant (I654V, rs1801201) in
Indexed as
ExomeGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGerm-Line MutationAdolescentAdultAgedBiomarkers, TumorChildDNA Mutational AnalysisErb-b2 Receptor Tyrosine KinasesExome SequencingFemaleGenetic TestingHumansMaleBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine Kinases
Identifiers
PMID33419763
PMCPMC8026518
OpenAlexW3121061284
What OpenQuestion holds
Textmetadata
LicenceTDM
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