Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2021
Perceived Social Support and Interpersonal Functioning as Predictors of Treatment Response Among Depressed Older Adults.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Role of Family Decision-Making and Perceived Social Support in the Mental Health of Mothers of Infants in Rural Western China.Depression and anxiety · 2025Trial
- Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Trial
- Prevalence, determinants, and Help-Seeking behavior for major depressive disorder symptoms in the Lesotho population: A multilevel analysis from the Lesotho demographic and health survey 2023-24.Social psychiatry and psychiatric epidemiology · 2026Article
- Differential Associations Between Perceived Social Support and Cognition in Older Adults With and Without Multiple Sclerosis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment.Geriatrics (Basel, Switzerland) · 2026Review
- Caregiver burden in forensic mental health settings: social impacts on caregivers of individuals with severe mental disorders.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026Article
- The Art of Nanoimmunobiotechnomedicine in Depression Management.Advanced pharmaceutical bulletin · 2025Review
- The relationship between social support and interpersonal self-efficacy among higher vocational college students: parallel mediation effects of anxiety and loneliness.BMC psychology · 2025Article
- Association between organizational characteristics of community-oriented mental health facilities and treatment adequacy. A multilevel analysis from Lombardy, Italy.Frontiers in health services · 2025Article
- The influence of emotion dysregulation and perceived social support on the link between childhood emotional abuse and depressive symptoms in college students: a moderated mediation model.Frontiers in psychiatry · 2025Article
- Advances in the assessment and study of suicide in late-life depression.Frontiers in psychiatry · 2025Review
- Recent Advances in Multimodal Non-Pharmacological Interventions for Late-Life Depression.Neuropsychiatric disease and treatment · 2025Review
- Online Depression Communities as a Complementary Approach to Improving the Attitudes of Patients With Depression Toward Medication Adherence: Cross-Sectional Survey Study.Journal of medical Internet research · 2024Article
- Impacts of inflammatory cytokines on depression: a cohort study.BMC psychiatry · 2024Article
- Improving social reward responsivity and social connectedness in psychotherapies for late-life depression: Engage & Connect as an example.Psychiatry research · 2023Article
- The association between perceived social support and cognition in older adults with and without multiple sclerosis.Multiple sclerosis and related disorders · 2023Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- Improving Interventions for Loneliness and Social Isolation in Late Life: The Potential Role of Positive Affect.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- The relationship between living arrangements and depression among older adults in Shandong, China: The mediating role of social support.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveSocial isolation is highly common in late life and is associated with devastating mental health and physical outcomes. This study investigated whether components of social isolation (marital status, perceived social support, and interpersonal problems) predict change in depression severity over the course of a brief adherence intervention delivered in a primary care setting.
methodA sample of 189 older adults with major depressive disorder were randomized to either an adherence intervention, "Treatment Initiation Program," or treatment as usual. Marital status, perceived social support and interpersonal problems were assessed at baseline. A mixed-effects regression was used to test whether these factors predicted the change trajectory in depression severity over 24 weeks.
resultsBeing married (F(2,176) = 6.60; p = 0.001), reporting higher perceived social support (F(2,177) = 4.70; p = 0.01), and fewer interpersonal problems (F(2, 176) = 4.34; p = 0.01) predicted lower depression severity on average over the course of 24 weeks.
conclusionSocial variables such as living in partnership, perceiving others as supportive, and reporting few interpersonal problems may reduce older adults' vulnerability to depression and enhance their ability to benefit from treatment. These findings can guide development of interventions that will target these social factors early in treatment to increase efficacy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.